… repair after AKI and their long-term consequences is critical to kidney health. The authors used lineagetracing of cycling cells and single-nucleus multiomics (profiling transcriptome and …
… lineage-tracing methods focusing on the mouse model system and consider the impact of these methods on our understanding of kidney … gene that is induced by kidneyinjury (Ngal) to …
M Buse, M Cheng, V Jankowski, M Lellig, V Sterzer… - Iscience, 2024 - cell.com
… in a murine AKI model, the unilateral ischemia-reperfusion injury (IRI). For lineagetracing, we analyzed the kidneys using single-cell profiling during disease development at various …
BD Humphreys - Kidney international supplements, 2011 - Elsevier
… Developing new therapeutic approaches to treat acute kidneyinjury requires a detailed … Lineagetracing to determine origin of epithelial cells after kidney repair. Genetically labeled …
W Zhang, C Gao, A Tsilosani… - American Journal …, 2022 - journals.physiology.org
… regenerate medullary tubules following severe injury. These data also suggest that progenitor cell pools and repair of kidneyinjury is regionally specific within the kidney. It should be …
… Recently, a single-nucleus multiomics technique has been adopted in Cre-loxP-based conventional lineagetracing to depict the cellular transition upon acute kidneyinjury and profile …
… genomic lineagetracing approaches. Finally, we discuss how these cutting-… lineage tracing techniques might be applied to kidney research. Established genetic lineagetracing …
E Stamellou, M Cheng, V Sterzer… - Nephrology Dialysis …, 2021 - academic.oup.com
… : Acute tubular injury accounts for the most common intrinsic cause for acute kidneyinjury (… as a uniform reaction of tubule cells triggered by injury. Our group was the first to identify an …
… the changes in cellular fate that can occur during kidneyinjury. With the advent of single-cell … Genetic lineagetracing in mouse has informed our understanding of mammalian kidney …