[HTML][HTML] Human kidney organoids and tubuloids as models of complex kidney disease

AB Nunez-Nescolarde, DJ Nikolic-Paterson… - The American journal of …, 2022 - Elsevier
… , and stromal populations. Another highlight was the generation of large kidney organoids
… present within these organoids, as well as an epithelial cell population positive for GATA3, a …

[HTML][HTML] Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

L Helms, S Marchiano, IB Stanaway, TY Hsiang… - JCI insight, 2021 - ncbi.nlm.nih.gov
… In this study, we cross-validate SARS-CoV-2’s impact on kidney organoids and clinical data
to … -CoV-2’s kidney tropism, acute cytopathic effects, systemic and kidney-specific proteomic …

Kidney organoid research: current status and applications

O Trush, M Takasato - Current Opinion in Genetics & Development, 2022 - Elsevier
… The authors independently generated two progenitor cell populations (MM and UB) and
generated kidney organoid with developing CD system. They revealed that hormones …

Physiology assays in human kidney organoids

BS Freedman - American Journal of Physiology-Renal …, 2022 - journals.physiology.org
… were recognized early on to contain endothelial cells, but these were present only as a
minor population and failed to successfully vascularize the podocytes to form glomeruli (2, 4). …

Advances and challenges toward developing kidney organoids for clinical applications

R Nishinakamura - Cell Stem Cell, 2023 - cell.com
Kidney organoids are currently used for disease modeling and drug discovery and may
eventually be applicable for clinical … However, currently available organoids are still immature …

Kidney organoids and tubuloids

FA Yousef Yengej, J Jansen, MB Rookmaaker… - Cells, 2020 - mdpi.com
… from large groups of patients to find a general treatment for a heterogenic patient population,
and in organoids from specific patients to provide personalized medicine. Furthermore, the …

Overcoming kidney organoid challenges for regenerative medicine

T Geuens, CA van Blitterswijk… - NPJ Regenerative …, 2020 - nature.com
clinic, there are critical challenges to overcome. Here, we will discuss recent advances and
remaining challenges for kidney organoidspopulations in current kidney organoid cultures. …

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

A Subramanian, EH Sidhom, M Emani… - Nature …, 2019 - nature.com
… To address this, we analyze organoids transplanted under the mouse kidney capsule and …
can score organoids for reproducibility, faithfulness and quality, that kidney organoids derived …

Kidney organoids: a pioneering model for kidney diseases

M Tekguc, RC Van Gaal, SGM Uzel, N Gupta… - Translational …, 2022 - Elsevier
… Of note, the single cell analysis in this study suggested the myofibroblast transition from
mesenchymal fibroblast populations in kidney organoids, which is consistent with a recent study …

Kidney organoids: current knowledge and future directions

N Khoshdel-Rad, A Ahmadi, R Moghadasali - Cell and Tissue Research, 2022 - Springer
… Single-cell analysis identified a population of SIX1 + /kinase insert domain protein receptor
(KDR) + NPCs as a potential source of de novo vessel formation that formed from day 11. …