l-Proline catalyzed one pot synthesis of α-aminonitriles
A Nasreen - Tetrahedron Letters, 2013 - Elsevier
… In the present study we extend the scope of the l-proline catalyzed synthesis of α-aminonitriles
45 and the results are presented here. In order to optimize the reaction conditions initially
we studied the efficacy of l-proline by taking catalytic amount of 20 mol % and benzaldehyde
(1 mmol), aniline (1 mmol), and TMSCN (1.2 mmol), in acetonitrile (5 mL) as model reaction,
the reaction gave corresponding 2-(N-anilino)-2-phenylacetonitrile with 95% yield in 2 h
(Table 1, entry 5). In the absence of … We believe that this l-proline promoted methodology …
45 and the results are presented here. In order to optimize the reaction conditions initially
we studied the efficacy of l-proline by taking catalytic amount of 20 mol % and benzaldehyde
(1 mmol), aniline (1 mmol), and TMSCN (1.2 mmol), in acetonitrile (5 mL) as model reaction,
the reaction gave corresponding 2-(N-anilino)-2-phenylacetonitrile with 95% yield in 2 h
(Table 1, entry 5). In the absence of … We believe that this l-proline promoted methodology …
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