Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the …

D Annane, SM Pastores, W Arlt, RA Balk… - Intensive care …, 2017 - Springer
… acid peptide produced from the cleavage of a large precursor, pro-opiomelanocortin. ACTH
… withdrawal, of glucocorticoid treatment may then cause symptoms of adrenal insufficiency [1…

[HTML][HTML] Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal …

H Raff, ST Sharma, LK Nieman - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
… so are used to treat a wide spectrum of diseases. For the most … As described for discontinuation
of glucocorticoid therapy in … The loss of negative feedback at the pituitary leads to a large

Therapy of adrenal insufficiency: an update

A Falorni, V Minarelli, S Morelli - Endocrine, 2013 - Springer
… The clinical picture is determined by the glucocorticoid deficit, … The clinical spectrum of
adrenal insufficiency has, however, … On the other hand, large use of grapefruit juice or licorice …

Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency

LA Metherell, D Naville, G Halaby… - The Journal of …, 2009 - academic.oup.com
… to chromosome 8 revealed a large region of homozygosity … birth and was diagnosed with
adrenal insufficiency at age 3 yr. … present with a spectrum of phenotypes. At one end of this …

Iatrogenic adrenal insufficiency in adults

J Martin-Grace, M Tomkins, MW O'Reilly… - Nature Reviews …, 2024 - nature.com
… (and its resultant hormone deficiency) falls within a spectrum … A large data base study in the
USA, which included >10,000 … is also known as glucocorticoid-induced adrenal insufficiency; …

Adrenal insufficiency in high-risk surgical ICU patients

EP Rivers, M Gaspari, M Mlynarek, HM Horst, J Fath… - Chest, 2001 - Elsevier
… The present study provides evidence for the existence of glucocorticoid-responsive shock
states in the severely ill ICU patient, and it also confirms that the standard criteria for abnormal …

Adrenal insufficiency in the surgical intensive care unit patient

E Barquist, O Kirton - Journal of Trauma and Acute Care Surgery, 1997 - journals.lww.com
… exogenous administration of glucocorticoids. The second … the rate of adrenal insufficiency
in a large population of ICU … failure to improve on broad spectrum antibiotics. We hoped that …

Mechanisms of bone fragility in a mouse model of glucocorticoid‐treated rheumatoid arthritis: implications for insufficiency fracture risk

M Takahata, JR Maher, SC Juneja… - Arthritis & …, 2012 - Wiley Online Library
Objective Glucocorticoid (GC) therapy is associated with increased risk of fracture in patients
with rheumatoid arthritis (RA). To elucidate the cause of this increased risk, we examined …

Evaluation and management of adrenal insufficiency in critically ill patients: disease state review

AH Hamrahian, M Fleseriu… - Endocrine Practice, 2017 - Elsevier
large body of literature. We review the clinical presentation, diagnosis, and treatment of adrenal
insufficiency … , respectively, may trigger need for glucocorticoid treatment. Assays of free …

Corticotropin tests for hypothalamic-pituitary-adrenal insufficiency: a metaanalysis

, … -Pituitary Adrenal Insufficiency - The Journal of …, 2008 - academic.oup.com
insufficiency (HPAI) is characterized by impaired ACTH secretion as a result of disease or
injury to the pituitary or hypothalamus or from prolonged exogenous glucocorticoidspectrum