Numerical and machine learning analysis of the parameters affecting the regionally delivered nasal dose of nano-and micro-sized aerosolized drugs

A Farnoud, H Tofighian, I Baumann, K Ahookhosh… - Pharmaceuticals, 2023 - mdpi.com
… micro-aerosols lead to highest doses in the vestibule and nasal valve regions. Consequently,
fine micro aerosols with low inlet airflow rates cause higher doses in the nasopharynx. For …

Machine learning and sensitivity analysis for predicting nasal drug delivery for targeted deposition

H Calmet, D Dosimont, D Oks, G Houzeaux… - International Journal of …, 2023 - Elsevier
… (2023) applied machine learning with CFD and reported that the aerosol diameter and …
delivered dose. In this study, we evaluate the ability of different machine learning algorithms to …

Considerations for the development of nasal dosage forms

JD Ehrick, SA Shah, C Shaw, VS Kulkarni… - … , Process, Quality and …, 2013 - Springer
… This process is experimental and the keywords may be updated as the learning algorithm
… This case study reviews the steps typically taken when selecting a multi-dose nasal spray …

Estimation of absorbed radiation doses to skin and s‐values for organs at risk due to nasal administration of PET agents using Monte Carlo simulations

J O'Doherty, CD Mangini, DM Hamby… - Medical …, 2021 - Wiley Online Library
… to estimate radiation dose to the skin inside a cylindrical model of the nasal cavity assuming
… We compared radiation doses from our simulated cylindrical geometry with the planar dose

Pharmacokinetics of concentrated naloxone nasal spray over first 30 minutes post‐dosing: analysis of suitability for opioid overdose reversal

G Mundin, R McDonald, K Smith, S Harris, J Strang - Addiction, 2017 - Wiley Online Library
… We present analysis of data from a study of concentrated naloxone nasal spray formulations.
Our … for overdose reversal in terms of naloxone absorption within 30 minutes post-dosing. …

[HTML][HTML] Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and …

J Wang, S Shen, B Yan, Y He, G Zhang, C Shan… - Environment …, 2023 - Elsevier
analysis was used to validate the interrelationships of the aforementioned factors. Finally,
machine learning … Finally, we developed a machine learning model to predict the CRSwNP …

Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity …

DS Quintana, LT Westlye, ØG Rustan, N Tesli… - Translational …, 2015 - nature.com
… the dose-dependency of these PD effects of OPN-OT. Last, we investigated the relationship
between nasal … Oxytocin enhances amygdala-dependent, socially reinforced learning and …

Daily versus self-adjusted dosing of topical mometasone furoate nasal spray in patients with allergic rhinitis: randomised, controlled trial

MA Khan, AS Abou-Halawa, AA Al-Robaee… - The Journal of …, 2010 - cambridge.org
… -adjusted dosage of mometasone furoate nasal spray gives … Patients should learn how to
control these symptoms with the … self-adjusted dosing of mometasone furoate nasal spray in …

Dose-related enhancement of mood and cognition in smokers administered nicotine nasal spray

CS Myers, RC Taylor, ET Moolchan… - …, 2008 - nature.com
… 2 mg nicotine via nasal spray in random order at 90 min intervals. Before and after each dose,
a … test (CPT) and an arithmetic test in a dose-related manner, but had no effect on working …

Effects of intranasal cocaine on human learning, performance and physiology

ST Higgins, WK Bickel, JR Hughes, M Lynn… - …, 1990 - Springer
… sensation in the nasal mucosa without … dose was administered in the present study is
consistent with earlier findings on this topic suggesting that intranasal cocaine may disrupt learning