Complement alternative and mannose-binding lectin pathway activation is associated with COVID-19 mortality

F Defendi, C Leroy, O Epaulard, G Clavarino… - Frontiers in …, 2021 - frontiersin.org
activation, and the mortality in COVID-19 patients (cluster 4). Our data are in line with Ma et
al. showing increased AP components in COVID-19 … AP activity and COVID-19 severity (22). …

[HTML][HTML] Complement activation via the lectin and alternative pathway in patients with severe COVID-19

J Niederreiter, C Eck, T Ries, A Hartmann… - Frontiers in …, 2022 - frontiersin.org
COVID-19-induced complement activation occurred via the lectin pathway, while activation of
the alternative pathway … higher COVID-19 severity and mortality (21). However, evidence of …

The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury

MAS Malaquias, AC Gadotti… - Translational …, 2021 - Elsevier
… Despite the excessive number of deaths resulting from the current pandemic COVID-19, very
few … Here, we described the massive activation of the lectin pathway, with consequences of …

Plasma lectin pathway complement proteins in patients with COVID-19 and renal disease

NR Medjeral-Thomas, A Troldborg… - Frontiers in …, 2021 - frontiersin.org
lectin pathway contributes to COVID-19 pathogenesis, we measured the plasma concentration
of 11 lectin … Black crosses mark patient deaths. Coloured bars show when patients met …

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

, … of Health Research (CITIID-NIHR) COVID … - Frontiers in …, 2023 - frontiersin.org
… Despite this, genetic variations in MBL2 are not associated with susceptibility to SARS-CoV-2
infection or disease outcomes such as mortality and the development of Long COVID. …

[HTML][HTML] The influence of the lectin pathway of complement activation on infections of the respiratory system

AS Świerzko, M Cedzyński - Frontiers in Immunology, 2020 - frontiersin.org
deaths than previously expected due to the pandemic of coronavirus disease 2019 (COVID-19), …
called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Complement …

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

A Rambaldi, G Gritti, MC Micò, M Frigeni, G Borleri… - Immunobiology, 2020 - Elsevier
… therapy (RECOVERY) trial, demonstrated that dexamethasone reduced 28-day mortality in
patients on invasive mechanical ventilation by 28.7 % (29.0 % versus 40.7 % with usual care)…

Mannose-binding lectin is associated with thrombosis and coagulopathy in critically ill COVID-19 patients

O Eriksson, M Hultström, B Persson… - Thrombosis and …, 2020 - thieme-connect.com
… significant morbidity and mortality, as well … lectin pathway of complement activation, binds
to coronaviruses[5] and has been proposed to participate in the host defense during COVID-19

Inhibition of the lectin pathway of complement activation reduces acute respiratory distress syndrome severity in a mouse model of SARS-CoV-2 infection

YM Ali, GW Carnell, S Fumagalli… - The Journal of …, 2024 - academic.oup.com
… The outbreak of COVID-19, a pandemic respiratory disease caused by SARS-CoV-2, is
responsible for critical health problems around the world, with a high rate of mortality, especially …

Lectin pathway mediates complement activation by SARS-CoV-2 proteins

YM Ali, M Ferrari, NJ Lynch, S Yaseen… - Frontiers in …, 2021 - frontiersin.org
… progressed to severe COVID-19 pathology. This report demonstrates that lectin pathway (LP) …
to severe long-term morbidity and mortality, especially in patients with underlying medical …