[HTML][HTML] Comparison of the pulmonary response against lethal and non-lethal intranasal challenges with two different pneumococcal strains

DM Ferreira, AT Moreno, AM Cianciarullo, PL Ho… - Microbial …, 2009 - Elsevier
… a model of intranasal challenge with a lethal serotype 3 strain and a non-lethal serotype 14
… levels in the spleen, serotype 14-challenged mice showed a decrease in mRNA levels of TNF…

Intranasal inoculate of influenza virus vaccine against lethal virus challenge

X Fan, Q Su, F Qiu, Y Yi, L Shen, Z Jia, P Liang, Y Zou… - Vaccine, 2018 - Elsevier
intranasal administration with H1N1 split vaccine in mice. We demonstrated that CTA1-DD-adjuvant
vaccine provided 100% protection against mortality and greatly reduced morbidity in …

[HTML][HTML] Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge

TY Wong, KS Lee, BP Russ, AM Horspool, J Kang… - npj Vaccines, 2022 - nature.com
… and route of administration. Our findings demonstrate that, unlike intramuscular administration,
intranasal administration of BReC-CoV-2 provided protection against lethal doses of both …

[HTML][HTML] Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge

RG King, A Silva-Sanchez, JN Peel, D Botta… - Vaccines, 2021 - mdpi.com
… Our data showed that intranasal administration of AdCOVID induced both monofunctional
… These data therefore indicated that intranasal administration of AdCOVID did not potentiate …

Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection

SH Hong, YH Byun, CT Nguyen, SY Kim, BL Seong… - Vaccine, 2012 - Elsevier
… We had previously shown that intranasally administered FlaB was mostly trapped by dendritic
… When we determined the protective immune response in the lethal challenge experiment, …

Intranasal administration of dry powder anthrax vaccine provides protection against lethal aerosol spore challenge

J Huang, JA Mikszta, MS Ferriter, G Jiang… - Human …, 2007 - Taylor & Francis
administered powder rPA vaccine to generate serum PA-specific antibody responses and
protect rabbits from lethal aerosol spore challenge… enables protection against lethal challenge …

[HTML][HTML] Intranasal administration of chitosan against influenza A (H7N9) virus infection in a mouse model

M Zheng, D Qu, H Wang, Z Sun, X Liu, J Chen, C Li… - Scientific Reports, 2016 - nature.com
… ODN) can protect mice from lethal virus challenges 21 .We previously … intranasal administration
of chitosan alone could completely protect BALB/c mice from lethal H7N9 viral challenges

Murine lethal toxic shock caused by intranasal administration of staphylococcal enterotoxin B

V Savransky, V Rostapshov, D Pinelis… - Toxicologic …, 2003 - journals.sagepub.com
… The mortality rate of mice challenged with 4.0 µg/g was 80%. Doses of 5.0 or 6.0 µg/g
were lethal to 100% of mice (Table 1). The LD50 dose for intranasal challenge of SEB was …

[HTML][HTML] Intranasal administration of adjuvant-combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infection

Y Asahi-Ozaki, S Itamura, T Ichinohe, P Strong… - Microbes and …, 2006 - Elsevier
… Anti-H5 HA-specific IgA and IgG responses in BALB/c mice and B10 mice, and their survival
rates after lethal challenge with H5N1 virus. Anti-H5 HA-specific IgA and IgG responses in …

[PDF][PDF] Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge …

RG King, A Silva-Sanchez, JN Peel, D Botta… - DOI: https://doi. org …, 2021 - academia.edu
… Finally, a single administration of AdCOVID completely protected K18-hACE2 mice from
lethal challenge. These data support the clinical development of AdCOVID in response to a …