SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells

K Meyer, T Patra, Vijayamahantesh, R Ray - Journal of virology, 2021 - Am Soc Microbiol
… an induction of paracrine endothelial cell senescence as a … leukocyte adhesion using a
fluorometric assay on the human monocyte cell line THP-1. A significant cellular adhesion of THP-…

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

A Lagnado, J Leslie, MH Ruchaud‐Sparagano… - The EMBO …, 2021 - embopress.org
… that senescent cells … senescence spreads to surrounding cells. Our results suggest that
interventions that counteract neutrophil‐induced senescence may be beneficial during aging and …

Dysregulation of leukocyte trafficking in ageing: Causal factors and possible corrective therapies

S Hopkin, JM Lord, M Chimen - Pharmacological Research, 2021 - Elsevier
… of senescent cells that drive modulated leukocyte trafficking. … The leukocyte adhesion
cascade has been reviewed in … Importantly, autocrine or paracrine stimulation of CXCR2 by …

Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α–dependent senescence-associated secretory phenotype

SE Gardner, M Humphry, MR Bennett… - … , and vascular biology, 2015 - Am Heart Assoc
… that senescent VSMCs actively secrete IL-1α that drives the SASP in an autocrine/paracrine
To confirm that senescent VSMCs could also induce leukocyte recruitment in vivo, we …

[HTML][HTML] Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients

AG Sorokina, YA Orlova, OA Grigorieva… - Experimental …, 2023 - Elsevier
The aim of the study was to investigate the relationship between established clinical systemic
biomarkers of ageing and the development of age-associated diseases and senescent cell …

Paracrine anti-inflammatory effects of adipose tissue-derived mesenchymal stem cells in human monocytes

MI Guillén, J Platas, MD Perez del Caz… - Frontiers in …, 2018 - frontiersin.org
Senescent cells exhibit increased cytoplasmic activity of SA-β-Gal (Dimri et al., 1995). To
examine whether CM may affect senescence, we characterized this process by the presence of …

Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype

B Schnabl, CA Purbeck, YH Choi, CH Hagedorn… - Hepatology, 2003 - Elsevier
… of leukocytes but might also exert paracrine and autocrine effects on HSCs. Several chemokines
found to be up-regulated in senescent … by expressing 2 leukocyte adhesion molecules, …

Senescent endothelial cells: potential modulators of immunosenescence and ageing

I Pantsulaia, WM Ciszewski, J Niewiarowska - Ageing Research Reviews, 2016 - Elsevier
paracrine senescence appears to be under control because transmissibility decreases during
the serial transfer of senescenceadhesion molecules to recruit pro-inflammatory leukocytes

Inflammatory signaling and cellular senescence

JL Ren, JS Pan, YP Lu, P Sun, J Han - Cellular signalling, 2009 - Elsevier
… compartment by senescent cells also have paracrine functions… to a progressive infiltration
of host leukocytes (neutrophils, … to attract these leukocytes, and adhesion molecules including …

Mechanisms and consequences of endothelial cell senescence

SI Bloom, MT Islam, LA Lesniewski… - Nature Reviews …, 2023 - nature.com
… endothelial cell senescence. We also discuss how endothelial cell senescence causes …
Finally, we summarize the latest evidence on the effect of eliminating senescent endothelial …