The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been … Cytokine storms (CSs) are associated
with various pathologies, … cytokine release and cell death pathways; certain cytokines, …

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors
including age and sample time point, patients with COVID-19 exhibited lower cytokine levels …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
… /chemokine receptor system largely contributed to the onset of the “cytokine storm”. … that
the cytokine/chemokine network is crucial in the onset and maintenance of the “cytokine storm”, …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
… a cytokine storm is lacking. Furthermore, there is not a good understanding of the molecular
events that precipitate a cytokine storm, of the contribution such a “storm” … Some have limited

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… currently a limited understanding of the cytokine storm in severe … treatment strategies for the
cytokine storm in severe COVID-19. … by neutrophils, may contribute to cytokine release. The …

The advent of the cytokine storm

IA Clark - Immunology and cell biology, 2007 - search.proquest.com
… The ICB Special Feature contribution on influenza36 has brought our attention to the
possibility of any treatment directed against the systemic inflammation that causes illness in this …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… and are of limited use in making prompt treatment decisions. … been shown to significantly
contribute to response amplification, … of cytokines and, thus, potentially contribute to CS [57]. …

[PDF][PDF] Cytokine storm

M Gaestel, AR Nebreda, MB Yaffe - 2021 - dspace.mit.edu
… Given the limited data on MAPK inhibitors for treating cytokine-storm disorders, we mentioned
MAPK only briefly, but we did include it as one of the four signaling pathways. We agree …

[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
… Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and …
IL-6 levels that were not associated with elevations in other canonical proinflammatory cytokines

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
… of pro-inflammatory cytokines and chemokines, which contribute to local tissue inflammation
… response called cytokine storm. Both local tissue inflammation and the cytokine storm play a …