… )-based vaccine strategy to induce liver Trm cells to prevent malaria. Although a standard
mRNA … a protective malaria vaccine, using conserved genes, for generation of liver Trm cells. …

… To better understand immune requirement for protection, we examined liver-stage
immunity after vaccination with irradiated sporozoites, an effective though logistically difficult …

… yoelii CSP-encoding DNA expressed in the liver of DNA-vaccinated mice drives Ag-…
vaccination were capable of giving rise to liver Trm cells, we performed HDT on ggCSP-vaccinated …

… Furthermore, this vaccine induced endogenous liver T RM cells that were long-… vaccine
platform for generating large numbers of liver T RM cells for effective control of liver-stage malaria …

… , the liver resident memory T cells, and the feasibility of their generation through vaccination
[… avenue for the generation of an effective liver-stage malaria vaccine. In this review, we will …

… 30% by vaccination. Vaccination boosted particle trapping capacity of the liver during crisis
when … It also attenuated malaria-induced inflammation, thus diminishing severe damages and …

… the liver 85 and retention of these memory T cells in the liver … Direct evidence that resident
cells could form in the liver, … T cells in the liver following vaccination and/or malaria challenge. …

… multiple candidate malaria vaccination strategies, likely after delivery of antigen to the liver.
… liver-resident memory CD8 + T cells (hepatic T RM ) play a critical role in providing protective …

… a liver-stage-specific T cell-mediated vaccine, we used a liver-directed LNP-based mRNA
vaccine platform and the rodent malaria … In this study, we aimed to develop a malaria vaccine …

… The investigators are hopeful that this vaccine can induce protective liver-resident T cells in
… to correlate with liver-stage protection. However, liver-stage malaria vaccines have struggled …