You shall not pass: memory CD8 T cells in liver-stage malaria

MN Lefebvre, JT Harty - Trends in parasitology, 2020 - cell.com
… immunization sculpts the memory CD8 T cell compartment of the human liver have not …
liver tissue. Significant phenotypic heterogeneity exists among RAS-responding memory CD8 T …

Detailed analysis of intrahepatic CD8 T cells in the normal and hepatitis C-infected liver reveals differences in specific populations of memory cells with distinct homing …

M Heydtmann, D Hardie, PL Shields, J Faint… - The Journal of …, 2006 - journals.aai.org
… response within the liver in chronic HCV (29). We, therefore, performed a detailed analysis
of effector and memory CD8 T cells infiltrating the human liver in end-stage HCV infection and…

Immunophenotypic shift of memory CD8 T cells identifies the changes of immune status in the patients after liver transplantation

Y Sun, S Yin, H Xie, L Zhou, Y Wang… - … Journal of Clinical and …, 2009 - Taylor & Francis
… of these phenotypes of memory CD8 + T cell subsets in the patients with acute liver rejection.
Importantly, an enrichment of naive CD8 + CD45RA + CD62L + or CD8 + CD27 + CD28 + …

Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection

D Fernandez-Ruiz, WY Ng, LE Holz, JZ Ma, A Zaid… - Immunity, 2016 - cell.com
… Here, we have undertaken a detailed assessment of liver-associated memory CD8 + T cells
liver-stage vaccine, RAS. We identified a population of CD8 + T cells that patrol the liver

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

Y Koda, T Teratani, PS Chu, Y Hagihara… - Nature …, 2021 - nature.com
… Here, using a murine diet-induced NASH and the subsequent resolution model, we
demonstrate direct roles of CD8 + tissue-resident memory CD8 + T (CD8 + Trm) cells in resolving …

Differential peripheral memory T cell subsets sensitively indicate the severity of nonalcoholic fatty liver disease

A Kado, T Tsutsumi, H Yotsuyanagi… - Hepatology …, 2024 - Wiley Online Library
… to become memory cells during the early stages of … liver fibrosis and pathological progression
in NAFLD. In vivo, CD4+ and CD8+ tissue-resident memory T cell subsets promote liver

Human liver memory CD8+ T cells use autophagy for tissue residence

L Swadling, LJ Pallett, MO Diniz, JM Baker, OE Amin… - Cell reports, 2020 - cell.com
… lymphocytes that reside in the liver showing the highest rates of … prototypical liver cytokine
IL-15, required for the induction of liver-… abrogates T RM cell programming of CD8 + T cells. …

Memory CD8 T Cells Specific for Plasmodia Liver-Stage Antigens Maintain Protracted Protection Against Malaria

U Krzych, S Dalai, S Zarling, A Pichugin - Frontiers in immunology, 2012 - frontiersin.org
… al., 2003) and antigen experienced CD44 hi CD8 T cells are found predominantly in the
liver (Guebre-Xabier et al., 1999). In this review, we mainly focus on memory CD8 T cells in the …

CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model

N Van Braeckel-Budimir, JT Harty - Frontiers in microbiology, 2014 - frontiersin.org
… The most important finding of the study was that the pathways of memory CD8 T-cell-mediated
protection against liver-stage infection were not completely overlapping for the two …

CD8+ T effector memory cells protect against liver-stage malaria

A Reyes-Sandoval, DH Wyllie, K Bauza… - The Journal of …, 2011 - journals.aai.org
CD8 + responses against the malaria liver-stage parasites (15). Viral vectors expressing
liver-stage … generation of memory T cell responses (20). Three major subsets of Ag-experienced …