Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
… and chemokines, which contribute to local tissue inflammation and a dangerous … inflammatory
response called cytokine storm. Both local tissue inflammation and the cytokine storm play …

[HTML][HTML] Understanding the cytokine storm during COVID-19: Contribution of preexisting chronic inflammation

P Miossec - European Journal of Rheumatology, 2020 - ncbi.nlm.nih.gov
… This leads to local cell damage in the alveoli, with local and systemic inflammation. In most
… , there is a massive storage of cytokines in adipose tissue. More importantly, in this context …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… production of massive inflammatory cytokines and chemical mediators. … Excessive local
release of cytokines is considered to be the … into the lung tissue, which results in a cytokine storm. …

The advent of the cytokine storm

IA Clark - Immunology and cell biology, 2007 - search.proquest.com
… concern local pathological events from these cytokines, those … cytokines in pancreatitis, along
with other examples of tissue … excessively activating systemic inflammation, is also covered …

Cytokine storm in COVID19: a neural hypothesis

A Ur, K Verma - ACS chemical neuroscience, 2020 - ACS Publications
tissue damage to the lung without severe microbial infections. In the lung, the cytokine storm
is characterized by a local inflammation … severity of local and systemic cytokine storms. But it …

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
… life-threatening damage to host tissues and organs. … inflammatory cell death, leading to
further cytokine secretion. Here, we discuss recent progress in innate immunity and inflammatory

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
local and systemic effects that are generally pro-inflammatory… Importantly, the release of IL-6
within an inflammatory milieu … components of the infected tissue and not necessarily part of …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
… accurate picture of the cytokine profiles in a tissue, in the lungs… the severity of local and
systemic cytokine storms. For example, … Inflammation associated with a cytokine storm begins at a …

[HTML][HTML] Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

D Panigrahy, MM Gilligan, S Huang, A Gartung… - Cancer and metastasis …, 2020 - Springer
… hyper-inflammation and potentially life-threatening “cytokine storms”. Controlling the local and
systemic inflammatory … production and promoting a return to tissue homeostasis [5, 7, 8]. In …

A novel therapeutic approach to modulate the inflammatory cascade: A timely exogenous local inflammatory response attenuates the sepsis-induced cytokine storm

M Gong, S Qi, Z Wu, Y Huang, L Wu, X Wang, L He… - Cytokine, 2024 - Elsevier
… It provides direct evidence that eLIR can serve as a mechanical signal to create controllable
tissue damage and low-scale inflammation in the skin tissue, leading to a remarkable profile …