Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

… As there is evidence for differences based on the epigenetic clock in other ethnic … of
longitudinal trajectories of the epigenetic clock across the life course, showing that epigenetic age …

… Horvath ad Levine epigenetic clocks are moderately heritable at and across old age. For
the Horvath clock, new genetic influences emerge with age but for the Levine clock, the same …

… in maintaining epigenetic … of epigenetic clock, estimated by a DNA methylation-based
methods, may be developmentally adjusted, and that individual’s discrepancies among epigenetic …

… Nevertheless, the literature on longitudinal studies investigating the relationship between …
, we present longitudinal data on the 7-CpG epigenetic clock and examine the longitudinal …

… that mitigates issues with reliability in standard epigenetic clock algorithms. We observed
a divergence in the epigenetic clock estimate PCPhenoAge and epigenetic clock mortality …

… At other times, researchers conducting longitudinal studies may find that methods have
changed since their original sample; follow-up research for samples originally run on the …

… and longitudinal assessments. Our results suggest that within a given domain (eg, epigenetic
clocks … correlated both cross–sectionally and longitudinally. In contrast, across domains …

… biological age estimators — epigenetic clocks, telomere length… — concluded that the
epigenetic clock is the most promising … in vitro studies, longitudinal mediation analyses of human …

… Moreover, the longitudinal changes in the epigenetic clock estimates occur at the same
rate as chronological ageing in LBC1936, which gives us confidence that they are tracking the …