Differential redistribution of activated monocyte and dendritic cell subsets to the lung associates with severity of COVID-19

I Sanchez-Cerrillo, P Landete, B Aldave… - MedRxiv, 2020 - medrxiv.org
… with uncontrolled inflammation in the lung and the activation of effector CD8 + T cells.
Therefore, our data highlight differential involvement of myeloid cell subsets in the pathogenesis of …

A cellular census of human lungs identifies novel cell states in health and in asthma

FA Vieira Braga, G Kar, M Berg, OA Carpaij… - Nature medicine, 2019 - nature.com
… Our single-cell analysis identifies differences in the proportions and … cells between upper
and lower airways and lung parenchyma. We identify a novel tissue-resident CD4 T cell subset

Building and regenerating the lung cell by cell

JA Whitsett, TV Kalin, Y Xu… - Physiological …, 2019 - journals.physiology.org
lung development. We will address fundamental issues related to the diversity of pulmonary
cells, to the formation and function of the mammalian lung, and … in lung organogenesis. What …

[HTML][HTML] Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

AM Leader, JA Grout, BB Maier, BY Nabet, MD Park… - Cancer cell, 2021 - cell.com
… Phenotype molding of stromal cells in the lung tumor … Phenotype molding of stromal cells
in the lung tumor … Phenotype molding of stromal cells in the lung tumor microenvironment. …

An integrated cell atlas of the human lung in health and disease

…, M Yoshida, Lung Biological Network Consortium… - BioRxiv, 2022 - biorxiv.org
Lung Cell Atlas (HLCA) combining 46 datasets of the human respiratory system into a single
atlas spanning over 2.2 million cells from … , or specific immune cell subsets are often hard to …

Phenotype molding of stromal cells in the lung tumor microenvironment

D Lambrechts, E Wauters, B Boeckx, S Aibar… - Nature medicine, 2018 - nature.com
… 52,698-cell catalog of the TME transcriptome in human lung tumors at single-cell resolution,
… The 9,756 myeloid cells clustered in 12 separate subsets (Fig. 4e). One cluster corresponds …

Non-small-cell lung cancers: a heterogeneous set of diseases

Z Chen, CM Fillmore, PS Hammerman, CF Kim… - Nature Reviews …, 2014 - nature.com
… define the specific subsets of NSCLC … lung cancer growth for each specific subset of NSCLC?
In this Review, we discuss how data that are derived from technological advances in lung

[HTML][HTML] Lung gene expression and single cell analyses reveal two subsets of idiopathic pulmonary fibrosis (IPF) patients associated with different pathogenic …

J Karman, J Wang, C Bodea, S Cao, MC Levesque - PLoS One, 2021 - journals.plos.org
subsets in IPF and showed that these subsets display different alterations in cellular composition
of the lung. … changes in disease to distinguish subsets. Specifically, we showed that one …

[HTML][HTML] Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses

Y Lavin, S Kobayashi, A Leader, ED Amir, N Elefant… - Cell, 2017 - cell.com
… -cell analysis of the tumor, non-involved lung, and blood cells, we provide a detailed immune
cell atlas of early lung … myeloid cell (TIM) subsets that likely compromise anti-tumor T cell

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

PA Reyfman, JM Walter, N Joshi… - American journal of …, 2019 - atsjournals.org
cells (basal cells) in the normal and fibrotic lung, and we largely confirmed the observation
that Axin2-positive alveolar type II cells are a minor subset of the murine alveolar type II cell