Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

JA Aguiar, BJM Tremblay, MJ Mansfield… - European …, 2020 - Eur Respiratory Soc
… variety of lung epithelial cell samples and low ACE2 gene expression in both … expression,
rare ACE2 protein expression was observed in the airway epithelium and alveoli of human lung

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

LT Bui, NI Winters, MI Chung, C Joseph… - Nature …, 2021 - nature.com
… outcomes in patients with chronic lung diseases. We observe a similar cellular distribution
and relative expression of SARS-CoV-2 entry factors in control and CLD lungs. CLD AT2 cells …

Tobacco smoking increases the lung gene expression of ACE2, the receptor of SARS-CoV-2

G Cai, Y Bossé, F Xiao, F Kheradmand… - American journal of …, 2020 - atsjournals.org
expression identified in this study may suggest an increased risk for viral binding and entry
of SARS-CoV and SARS-CoV-2 in lungs of … TMRPSS2 gene expression in lung was not …

Expression of elevated levels of pro‐inflammatory cytokines in SARSCoV‐infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis …

L He, Y Ding, Q Zhang, X Che, Y He… - The Journal of …, 2006 - Wiley Online Library
… human ACE2 protein and the SARS-CoV S protein by IHC, … analysed the expression of both
ACE2 and SARS-CoV S … the lungs and other organs of four patients who died of SARS and …

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

MY Li, L Li, Y Zhang, XS Wang - Infectious diseases of poverty, 2020 - mednexus.org
… Our data indicate that SARS-CoV-2 may infect other tissues aside from the lungs and infect
persons with different sexes, ages, and races equally. The different host immune responses …

Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

AJ Pruijssers, AS George, A Schäfer, SR Leist… - Cell reports, 2020 - cell.com
SARS-CoV-2 and future emerging CoVs. We report that remdesivir (RDV) potently inhibits
SARS-CoV-2 replication in human lung … engineered a chimeric SARS-CoV encoding the viral …

Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection

Q Kong, Z Xiang, Y Wu, Y Gu, J Guo, F Geng - Molecular Cancer, 2020 - Springer
… two common lung cancers, lung adenocarcinoma (LUAD) and lungexpression differences
in ACE2 and TMPRSS2 between these lung cancers and their relationships with SARS-CoV

Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium

BA Schuler, AC Habermann, EJ Plosa… - The Journal of …, 2021 - Am Soc Clin Investig
lung with temporally resolved immunofluorescence in mouse and human lung tissue, we
found that expression of SARS-CoV-… (AT1), and TMPRSS2 expression increased with aging in …

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis

J Xu, X Xu, L Jiang, K Dua, PM Hansbro, G Liu - Respiratory research, 2020 - Springer
… In this study, we found that SARS-CoV-2 infection induced FN1 gene expression in alveolar
epithelial cells, indicating the early induction of fibrotic processes and how the virus may be …

[HTML][HTML] In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19

IM Schaefer, RF Padera, IH Solomon, S Kanjilal… - Modern Pathology, 2020 - Elsevier
… We examine in situ expression of SARS-CoV-2 in airways and lung obtained at autopsy of
individuals with confirmed COVID-19 infection. Seven autopsy cases (male, N = 5; female, N = …