… that normally governs ACE2 levels, some aspects of infection or … In this study, we evaluated
SARS-CoV-2 infection of mice … Human ACE2 was expressed in the nasal turbinate, lung, …

… in humans who have been hospitalized. Here, we evaluate transgenic mice expressing the
human angiotensin I-converting enzyme 2 (ACE2) … -CoV-2 infection. Intranasal inoculation of …

… Results We found, using single-cell RNA sequencing of distal human nondiseased lung …
recombinant human ACE2 protein and cell lysates from HEK cells overexpressing human ACE2 …

… , human ACE2-transgenic mice, and human ACE2 knock-in mice. Body weight changes,
viral genome copies in organ tissues, and the lung histopathology of infected … infection risk of …

… of the brain was the major contributory factor in a fatal outcome, we also detected changes
in the lungs consistent with aspiration, present only in K18-hACE2 mice at day 4 pi, that …

… CoV-2 infection, we identify human H522 lung adenocarcinoma cells as … infection, we
infected a panel of human lung and head/neck cancer cell lines expressing varying levels of ACE2 …

… human cases. Here, we evaluate heterozygous transgenic mice expressing the human ACE2
… hACE2) as a model of SARS-CoV-2 infection. Intranasal inoculation of SARS-CoV-2 in K18…

… susceptible to coronavirus infection than the healthy population. To do this, we analyzed
the expression of ACE2 in lung in different populations. The expression level of ACE2 was not …

… Focus of this review is to dissect the knowledge on ACE2 receptor on airway and lung
epithelium and attempt to understand whether underlying diseases or therapies are able to …

… vivo infected human lung tissue, COVID-19 autopsy material and adult stem cell derived
human lung organoids, we demonstrate scarce ACE2 … significant induction of ACE2 protein by …