SARS-CoV-2 infection and lung regeneration

F Zhao, Q Ma, Q Yue, H Chen - Clinical Microbiology Reviews, 2022 - Am Soc Microbiol
lung regeneration after SARS-CoV-2 infection. Moreover, clinical treatments may also affect
lung … In this review, we highlight how SARS-CoV-2 disrupts a program that governs lung

[HTML][HTML] Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19

RB Polidoro, RS Hagan, R de Santis Santiago… - Frontiers in …, 2020 - frontiersin.org
… understandings of lung physiology, where local infections progress … SARS-CoV-2 infection
into four phases: (1) Upper and lower respiratory tract infection, (2) COVID-19 associated lung

[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… Increased PAI1 expression was also observed in mice infected with SARS-CoV 113 .
Interestingly, in this mouse model, PAI1 protected mice from extensive lung haemorrhage, which …

[HTML][HTML] SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova… - Nature, 2021 - nature.com
… in vivo infection with SARS-CoV-2 in human lunglung tissues of LoM infected with SARS-CoV
or SARS-CoV-2 (Extended Data Fig. 2a). Consistent with previous results 17 , MERS-CoV

Pathological post‐mortem findings in lungs infected with SARSCoV‐2

S Damiani, M Fiorentino, A De Palma… - The Journal of …, 2021 - Wiley Online Library
… of lungs with severe SARS-CoV-2 infection in our series confirms the presence of DAD in
different evolution phases associated with variable co-morbidities and super-infections. …

[HTML][HTML] SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

D Wendisch, O Dietrich, T Mari, S von Stillfried… - Cell, 2021 - cell.com
… basis of lung injury remains incompletely understood. Here, we analyze pulmonary immune
responses and lung … In conclusion, we demonstrate that SARS-CoV-2 triggers profibrotic …

[HTML][HTML] Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

AA Salahudeen, SS Choi, A Rustagi, J Zhu… - Nature, 2020 - nature.com
… Our organoids also enable facile exploration of SARS-CoV-2 distal lung infection, … infection
could compromise protective lung glycosaminoglycans and precipitate a vicious infection

… of elevated levels of pro‐inflammatory cytokines in SARSCoVinfected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS

L He, Y Ding, Q Zhang, X Che, Y He… - The Journal of …, 2006 - Wiley Online Library
… The authors have previously shown that acute lung injury (ALI) produces a wide spectrum of
… (SARS) and that the SARS coronavirus (SARS-CoV) nucleoprotein is detectable in the lungs

[HTML][HTML] SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

A Mulay, B Konda, G Garcia, C Yao, S Beil, JM Villalba… - Cell reports, 2021 - cell.com
lung epithelial infection models to understand initial responses of proximal and distal lung
epithelium to SARS-CoV-2 infection… of distal lung AT2 cells are readily infected by SARS-CoV-…

[HTML][HTML] Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang… - Nature …, 2021 - nature.com
SARS-CoV-2 and SARS-CoV infection of the human lungs, we treated ex vivo human lung
tissues with NA, followed by SARS-CoV-2 or SARS-CoV challenge. Our results showed that …