Therapeutic targets in lung tissue remodelling and fibrosis

G Liu, AM Philp, T Corte, MA Travis, H Schilter… - Pharmacology & …, 2021 - Elsevier
… factor in the development of tissue remodelling that results in symptoms and impaired lung
function in these diseases. Tissue remodelling in the lungs is complex and differs between …

Tissue remodelling in pulmonary fibrosis

L Knudsen, C Ruppert, M Ochs - Cell and tissue research, 2017 - Springer
… Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
… Because of its progressive character leading to a rapid decline in lung function, it is a fatal …

Remodelling of peripheral lung tissue in COPD

JC Hogg, RA Pierce - European Respiratory Journal, 2008 - Eur Respiratory Soc
… This inflammatory immune response is inextricably linked to a repair and remodelling
destruction of gas-exchanging tissue [6, 7]. Although the lungs from most patients with COPD have …

[HTML][HTML] Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic …

NJ Lomas, KL Watts, KM Akram… - … journal of clinical and …, 2012 - ncbi.nlm.nih.gov
… Our results suggest that tissue remodelling in IPF is a complex processes involving
multiple cellular and biological factors within a dynamic cascade in which EMT may be one …

Inflammation‐associated remodelling and fibrosis in the lung–a process and an end point

WAH Wallace, PM Fitch, AJ Simpson… - International Journal …, 2007 - Wiley Online Library
… with scar tissue. We suggest that the term ‘lung remodelling’ should be used as a descriptor
for the dynamic repair multi-step process that occurs in the lung following inflammatory injury…

[HTML][HTML] Advances in mechanisms of repair and remodelling in acute lung injury

CC Dos Santos - Intensive care medicine, 2008 - Springer
… of profibrotic stimuli irreversible changes in extracellular matrix architecture occurs resulting
in erratic remodelling of the lung parenchyma, resulting in a gain of abnormal function …

Lung damage and airway remodelling in severe asthma

CE Brightling, S Gupta, S Gonem… - Clinical & Experimental …, 2012 - Wiley Online Library
lung damage and remodelling as this needs to be considered across multiple scales from
tissue to organ, cell to tissue … of airway damage and remodelling in the context of these scales …

[HTML][HTML] Lung tissue remodelling in MCT-induced pulmonary hypertension: A proposal for a novel scoring system and changes in extracellular matrix and fibrosis …

M Franz, K Grün, S Betge, I Rohm… - Oncotarget, 2016 - ncbi.nlm.nih.gov
remodelling. We studied lung tissue remodelling in a rat model of PH with special focus on
histology and extracellular matrix (ECM) remodelling. After induction of PH by monocrotaline, …

Matrix proteoglycans and remodelling of interstitial lung tissue in lymphangioleiomyomatosis

MJ Merrilees, EJ Hankin, JL Black… - The Journal of …, 2004 - Wiley Online Library
… Areas of interstitial tissue stained strongly for the matrix … Comparatively normal alveolar
walls in LAM lung also stained … to the expanded and remodelled interstitial lung tissue of LAM …

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

SG Royce, Y Moodley, CS Samuel - Pharmacology & therapeutics, 2014 - Elsevier
lung disease is characterized by ongoing and often progressive lung injury that results in
tissue remodelling … acute exacerbations in the setting of airway remodelling in severe asthma). …