Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis

V Aumiller, B Strobel, M Romeike, M Schuler… - Scientific reports, 2017 - nature.com
… In summary, we provide the first systematic comparison of lysyl oxidase expression in
experimental and clinical pulmonary fibrosis and their functional involvement in fibroblast to …

Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression

JW Chien, TJ Richards, KF Gibson… - European …, 2014 - Eur Respiratory Soc
… models of fibrotic disease (eg. lung fibrosis and liver fibrosis), … In a therapeutic murine model
of pulmonary fibrosis, GS-… levels in the lung, reduce factors that reflect fibrotic activity (eg. …

Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis

G Tjin, ES White, A Faiz, D Sicard… - Disease models & …, 2017 - journals.biologists.com
… Collagen organization and lysyl oxidase family of enzymes are differentially expressed and
… images of lysyl oxidase enzymes in the lungs. Images are representative of lung tissues from …

Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation

T Cheng, Q Liu, R Zhang, Y Zhang… - Journal of molecular …, 2014 - academic.oup.com
lysyl oxidase (LOX), have been proposed as potential therapeutic targets for idiopathic
pulmonary fibrosis. … in bleomycin (BLM)-induced lung fibrosis, and knockdown of LOX expression …

Properties and function of lysyl oxidase

HM Kagan, PC Trackman - Am J Respir Cell Mol Biol, 1991 - atsjournals.org
… Induction of lung fibrosis by exposure to agents such as bleomycin and cadmium is … in
lung lysyl oxidase activity (1). The elevated enzyme activity in cadmium-exposed rat lung was …

Lysyl oxidase–like 1 protein deficiency protects mice from adenoviral transforming growth factor-β1–induced pulmonary fibrosis

PS Bellaye, C Shimbori, C Upagupta… - American Journal of …, 2018 - atsjournals.org
Lysyl oxidase-like (LOXL) 1 belongs to the cross-linking enzyme family and has been shown
to be up-regulated in active fibrotic … are protected from experimental lung fibrosis induced by …

N-acetylcysteine downregulation of lysyl oxidase activity alleviating bleomycin-induced pulmonary fibrosis in rats

S Li, X Yang, W Li, J Li, X Su, L Chen, G Yan - Respiration, 2012 - karger.com
pulmonary fibrosis in hamsters. Thus, LOX may be a critical target of antifibrosis [24]. … In
this study, we examined whether NAC attenuates pulmonary fibrosis by modulation of LOX …

Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis

W Chen, A Yang, J Jia, YV Popov, D Schuppan… - …, 2020 - Wiley Online Library
Lysyl oxidase promotes bleomycin-induced lung fibrosis … of cavernosal fibrosis and erectile
function by Lysyl oxidase … Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused …

Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis

J Wang, Y Zhu, J Tan, X Meng, H Xie, R Wang - Molecular BioSystems, 2016 - pubs.rsc.org
Lysyl oxidase (LOX) is a copper-dependent amine oxidase that plays a critical role in pulmonary
fibrosis… with paraquat (PQ) induced pulmonary fibrosis. This present study was aimed to …

LOX/LOXL in pulmonary fibrosis: potential therapeutic targets

L Chen, S Li, W Li - Journal of drug targeting, 2019 - Taylor & Francis
… , EC 1.4.3.13), a copper-dependent amine oxidase, … lysyl oxidase isoenzymes have been
characterised in addition to LOX, designated lysyl oxidase-like (LOXL)-1 through lysyl oxidase-…