The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1

W Miao, J Chen, L Jia, J Ma, D Song - Biochemical and biophysical …, 2019 - Elsevier
… Our results indicate that METTL3 silence decreased the m6A level and mRNA level of … m6A
level of LEF1 is responsible for m6A methyltransferase METTL3-induced OS cell progression

Dysregulated m6A-related regulators are associated with tumor metastasis and poor prognosis in osteosarcoma

J Li, B Rao, J Yang, L Liu, M Huang, X Liu, G Cui… - Frontiers in …, 2020 - frontiersin.org
… To explore the underlying mechanism involved in m6A modification–mediated OS progression,
we performed a systematic bioinformatic analysis based on an OS genome meta-cohort. …

METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification

X Zhou, Y Yang, Y Li, G Liang, D Kang… - Frontiers in Cell and …, 2022 - frontiersin.org
… : Osteosarcoma (OS) is the most prevalent bone cancer among children and adolescents,
with relatively high mortality rates. RNA N6-methyladenosine (m6A) is … via m6A modification-…

Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma

Y Zhang, Y Wang, L Ying, S Tao, M Shi, P Lin… - Frontiers in …, 2021 - frontiersin.org
… Silencing ELAVL1 inhibits osteosarcoma progression by decreasing the expression of
DRG1 in an m 6 A-dependent pattern (66). These processes have been summarized in Table 1 …

Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value

H Liu, G Qin, Y Ji, X Wang, H Bao, X Guan… - Journal of Orthopaedic …, 2021 - Springer
… methylation regulators in tumor genesis and progression, we comprehensively … all m6A
methylation regulators and osteosarcoma using the TCGA dataset. The expression levels of m6A

Analysis and identification of m6A RNA methylation regulators in metastatic osteosarcoma

H Huang, X Cui, X Qin, K Li, G Yan, D Lu… - … Therapy-Nucleic Acids, 2022 - cell.com
Osteosarcoma (OS) is characterized by rapid growth and early metastasis. However, its
mechanism remains unclear. N 6 -methyladenosine (m 6 A) modification and its regulatory …

N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis

Z Ren, Y Hu, J Sun, Y Kang, G Li, H Zhao - Bioengineered, 2022 - Taylor & Francis
… Clinical data unveiled that osteosarcoma patients with higher FOXD2-AS1 … the osteosarcoma
progression through m 6 A manner, which may provide new concepts for osteosarcoma

METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m6A‐dependent manner

J Cheng, Z Xu, W Tan, J He, B Pan… - Journal of Cellular …, 2024 - Wiley Online Library
… assays, METTL16 facilitated OS cell progression by promoting the … progression. According
to the KEGG analysis and our experiment data, METTL16/VPS33B regulated the progression

The role of m6A methylation in osteosarcoma biological processes and its potential clinical value

Y Wu, Z Wang, J Shen, W Yan, S Xiang, H Liu… - Human genomics, 2022 - Springer
… , and progression in OS. This paper reviews the relationship between m6A methylation and
OS: m6A … We also discuss the potential clinical applications and future directions of m6A

Identification of osteosarcoma m6A-related prognostic biomarkers using artificial intelligence: RBM15

J Jiang, H Qu, X Zhan, D Liu, T Liang, L Chen… - Scientific Reports, 2023 - nature.com
… of m6A methylation modification in osteosarcoma are not fully understood, the main
objective of this study was to explore prognostic biomarkers associated with m6A methylation …