The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1

W Miao, J Chen, L Jia, J Ma, D Song - Biochemical and biophysical …, 2019 - Elsevier
… METTL3-induced OS cell progression. However, further in vivo studies needed to be … m6A
methyltransferase METTL3 contributes to the OS cell progression through regulating the m6A

N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis

Z Ren, Y Hu, J Sun, Y Kang, G Li, H Zhao - Bioengineered, 2022 - Taylor & Francis
… of FOXD2-AS1, and m 6 A methyltransferase WTAP (Wilms’ tumor 1 associated … osteosarcoma
progression through m 6 A manner, which may provide new concepts for osteosarcoma

The role of m6A methylation in osteosarcoma biological processes and its potential clinical value

Y Wu, Z Wang, J Shen, W Yan, S Xiang, H Liu… - Human genomics, 2022 - Springer
m6A methylation in OS and discuss future research directions and potential clinical applications
of RNA methyltransferases … are critical for tumor initiation, promotion, and progression in …

METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification

X Zhou, Y Yang, Y Li, G Liang, D Kang… - Frontiers in Cell and …, 2022 - frontiersin.org
… Previous studies indicated that methyltransferase-like 3 (METTL3), the first methyltransferase
to … However, its functions and underlying mechanisms in OS progression remain unclear; …

Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma

Y Zhang, Y Wang, L Ying, S Tao, M Shi, P Lin… - Frontiers in …, 2021 - frontiersin.org
… a multicomponent m 6 A methyltransferase complex (MTC) (27). Methyltransferase-like 3 (METTL3…
Silencing ELAVL1 inhibits osteosarcoma progression by decreasing the expression of …

Dysregulated m6A-related regulators are associated with tumor metastasis and poor prognosis in osteosarcoma

J Li, B Rao, J Yang, L Liu, M Huang, X Liu, G Cui… - Frontiers in …, 2020 - frontiersin.org
… To explore the underlying mechanism involved in m6A modification–mediated OS progression,
we performed a systematic bioinformatic analysis based on an OS genome meta-cohort. …

Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value

H Liu, G Qin, Y Ji, X Wang, H Bao, X Guan… - Journal of Orthopaedic …, 2021 - Springer
… regulated by methyltransferases (writers), m6A-binding proteins (… progression, we
comprehensively analyzed the relationship between all m6A methylation regulators and …

Analysis and identification of m6A RNA methylation regulators in metastatic osteosarcoma

H Huang, X Cui, X Qin, K Li, G Yan, D Lu… - … Therapy-Nucleic Acids, 2022 - cell.com
… Considering the important role played by m 6 A RNA methylation regulation factors in the
initiation and progression of tumors, we used genome-wide data of 88 OS cases from the …

Integrated Analysis of Transcriptome-Wide m6A Methylome of Osteosarcoma Stem Cells Enriched by Chemotherapy

Y Wang, L Zeng, C Liang, R Zan, W Ji, Z Zhang… - …, 2019 - Taylor & Francis
Osteosarcoma (OS) is the most common malignant bone … Emerging evidences have indicated
that osteosarcoma stem … of the methyltransferase complex that catalyze m6A modification, …

[HTML][HTML] METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4

X Huo, D Lu, D Chen, M Ye, X Wang… - Frontiers in Bioscience …, 2024 - imrpress.com
… (Methyltransferase 3) expression in osteosarcoma cells. We … in osteosarcoma and interferes
with METTL3 expression in … with tumorigenesis and cancer progression. In clear cell renal …