… Nuclear factor-κB (NF-κB) has long been known to … , NF-κB is a promising target for the
discovery of anti-inflammatory drugs. More recently, NF-κB has also emerged as a major culprit in …

… up major culprits in the pathogenesis of endometriosis. In this review, I shall present the case
against NF- κ B as a major culprit … , NF- κ B actually does not have a watertight alibi. In fact, …

Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF-κB …

… However, it was unknown whether IKKβ itself, or its downstream target, NF-κB, plays major
roles in insulin resistance. New data suggest that NF-κB and NF-κB-regulated cytokines are …

… NF-κB acts as a major transcription factor on the chromatin of senescent cells, and thus
controls both the cell-autonomous and non-cell-autonomous aspects of the senescence program …

… In the classical pathway, the activation of IKK is considered a major mechanism of NF-KB
activation, however, in certain … 113 Haefner B, NF-kappa B: Arresting a major culprit in cancer. …

… NF-κB also regulates the production receptors that are involved in immune recognition [eg
major histocompatibility complex (MHC)] and cytokines [eg IL-2, IL-12 and interferon (IFN)-γ] …

… of NF-κB activation by increasing the affinity of NF-κB for IκBα. In summary, NF-κB acts at the
crossroads of many signalling pathways. Inappropriate or excessive activation of NF-κB can …

… factor NF-κB serving as the major lynchpin. Here we review the function of NF-κB in linking
… issues, such as the relationship between NF-κB activation and abnormal growth signaling, …

… DM(II), CAD and CAN are major diseases in the US population that are underscored by
NF-κB activation. While all of these diseases have a complicated pathology, it seems clear that …