… and after major structural and cultural changes, in order to examine how such changes
related to the making of major discoveries. Despite our emphasis on the common structural and …

… metagenomic enzyme discovery [90]. The human gut microbiome has become a major target
… for novel CAZyme activities by integration of genomic context with structural modelling. The …

… optimization is a major challenge in drug discovery research. … based drug discovery,
called SeeDs (Structural exploitation … and protein crystal structures to characterize binding. …

… One of the major bottlenecks would be an extraction of because it is the most time-consuming
job. An integrated structural restraints from NOESY spectrum platform for automatic data …

… structure alone cannot provide conclusive information, and that the structural effort needs to
be integrated … delivered the expected major breakthrough in drug discovery may be the fact …

… Structure-based screening represents an integrated approach for the identification and …
Structure-based optimization of NMR hits Using structural information there are two major routes …

… declined at several major pharmaceutical companies. … the discovery of drug leads [146,
147]. We must therefore focus on our present knowledge and how best to apply it in an integrated …

… adopts its complex and integrated structure represent major frontiers. The mechanisms that
… Future advances in cardiac biology and molecular medicine will be driven by the integration …

… , or how types of organizations, or the structures and cultures of individual organizations are
… for such communication and integration? In our study of 290 major discoveries, every single …

… integration of several disciplines, which has influenced all areas of life sciences including that
of drug discovery. … Although one of the major disadvantages of a drug cocktail compared to …