… for the study of scientific discovery. Then, we summarize the major approaches and provide
… This categorization might provide a starting point for the integration of these different models …

… The last 20 years have seen a major change … discovery processes for better handling of
data associated with complex molecular mechanisms, requiring extensive integration of structure …

… Three major discoveries have recently profoundly modified … in natural environments; structural
biologists have shown that … become cellular following the integration of viral genomes into …

… discovery more efficient and reliable. In this review article, we discuss how the integration of
state-of-the-art structural, … of network theory for protein dynamic analysis thus plays a major …

… Although the integration reaction is known to be catalyzed by the viral integrase (… integration
step in LEDGF/p75-deficient cells, and the characteristic lentiviral preference for integration …

… , constantly revealing the structural complexity and new … of metabolites that translate into
the structure, function, and dynamics … the structure of unknown metabolites, represents a major …

… combine LB and SB techniques, integrating them in a holistic … enhance the success of drug
discovery projects. In this review, … its target is a major challenge in drug discovery. In the late …

… major biomedical research institutions in the United States in recent years have started
developing academic drug-discovery … Given the rapid advances in our understanding of structure-…

… This article also covers current practices for integrating data … the major limitation of X-ray
crystallography, but also to provide complementary structural data that is useful in drug discovery…

… for target discovery has been recognised as a major hurdle. … that has an impact on drug
discovery applications. The focus will … and structural diversity of proteins pose major obstacles for …