Structural bioinformatics in drug discovery

EB Fauman, AL Hopkins, CR Groom - Structural bioinformatics, 2003 - Wiley Online Library
… another major cornerstone of modern drug discovery, the … discovery projects are bathed in
structural and sequence information, it is the role of the structural bioinformatician to integrate

[HTML][HTML] Natural products in drug discovery: advances and opportunities

AG Atanasov, SB Zotchev, VM Dirsch… - … reviews Drug discovery, 2021 - nature.com
… their structural analogues have historically made a major … also accelerate NP-based
drug discovery. Irish, Bachmann, … profiling of bioactivity by integrating phospho-specific flow …

[图书][B] Integrating discovery-based research into the undergraduate curriculum: Report of a convocation

…, Committee for Convocation on Integrating Discovery … - 2015 - books.google.com
… Bringing research experiences into the academic year course structure will provide … identified
major concepts and issues that emerged during the workshop. These major concepts and …

Global, local and personalised modeling and pattern discovery in bioinformatics: An integrated approach

N Kasabov - Pattern Recognition Letters, 2007 - Elsevier
… study of major modeling and pattern discovery approaches … ), and a framework for the
integration of global, local and … Genes are complex molecular structures that cause dynamic …

G-Protein coupled receptors: structure and function in drug discovery

CS Odoemelam, B Percival, H Wallis, MW Chang… - RSC …, 2020 - pubs.rsc.org
… The first major breakthrough in human GPCR structural biology took … This base of structural
information on GPCRs is vital for … integrated models which complement drug discovery efforts. …

An integrated approach to empirical discovery

B Nordhausen, P Langley - 1989 - escholarship.org
… However, order effects can have a major impact on the structure of a taxonomy formed from
observational data, and thus on the laws the system finds. Of course, any incremental hill-…

Interaction networks: from protein functions to drug discovery. A review

E Chautard, N Thierry-Mieg, S Ricard-Blum - Pathologie Biologie, 2009 - Elsevier
… targets and for drug discovery. A major challenge is now to integrate data from different sources
… Protein structure information have been combined with protein interaction data to identify …

The Protein Data Bank (PDB), its related services and software tools as key components for in silico guided drug discovery

J Kirchmair, P Markt, S Distinto… - Journal of medicinal …, 2008 - ACS Publications
… a protein structure was a major event for the scientific community and considerable efforts
were taken to check the structure … into an integrated benchmarking environment to the Protein …

Genome wide prediction of protein function via a generic knowledge discovery approach based on evidence integration

J Xiong, S Rayner, K Luo, Y Li, S Chen - BMC bioinformatics, 2006 - Springer
… One of the major challenges now facing researchers is how to process this data to yield …
(A) Overview of the data integration and the validation process. (B) GO structure and the …

[图书][B] Reasoning in biological discoveries: Essays on mechanisms, interfield relations, and anomaly resolution

L Darden - 2006 - books.google.com
… -breaking foray into one of the major problems – biological mechanisms – facing … integrated
important discoveries about the mechanism of protein synthesis. This extended discovery