Clinical development of RTS, S/AS malaria vaccine: a systematic review of clinical Phase I–III trials

ST Agnandji, JF Fernandes, EB Bache… - Future …, 2015 - Taylor & Francis
… The first clinical Phase III trial evaluating a malaria vaccine was completed in December …
of Phase I–III trials including malaria-naive adults and adults, children and infants from malaria

A review of malaria vaccine clinical projects based on the WHO rainbow table

L Schwartz, GV Brown, B Genton, VS Moorthy - Malaria journal, 2012 - Springer
… and Phase 3 testing of the most advanced malaria vaccine, RTS,S/AS01, indicates that malaria
vaccine R&D is moving into a new phase… Field trials of several research malaria vaccines

Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

FM Thompson, DW Porter, SL Okitsu, N Westerfeld… - PLoS …, 2008 - journals.plos.org
… in a Phase I study in Switzerland and found to be safe and immunogenic [12], [14]. We
report a Phase I/IIa sporozoite challenge study that indicates that this bivalent peptide vaccine

Advances and challenges in malaria vaccine development

PD Crompton, SK Pierce… - The Journal of clinical …, 2010 - Am Soc Clin Investig
malaria in phase II clinical trials and is currently being evaluated in a … New vaccine targets
need to be identified to improve the chances of developing a highly effective malaria vaccine. …

Malaria vaccine clinical trials: what's on the horizon

A Moreno, C Joyner - Current opinion in immunology, 2015 - Elsevier
… novel vaccine candidates. In this review, recently completed and ongoing malaria vaccine
clinical trials as well as vaccinemalaria vaccine candidate, has reached phase 3 testing in the …

Malaria vaccine adjuvants: latest update and challenges in preclinical and clinical research

E Mata, A Salvador, M Igartua… - BioMed Research …, 2013 - Wiley Online Library
clinical development of diverse malaria vaccine candidates, considering the most relevant
vaccines and clinical … Although glycolipid compounds have progressed to clinical phase as …

[HTML][HTML] Malaria vaccine development: the need for novel approaches: a review article

S Mahmoudi, H Keshavarz - Iranian journal of parasitology, 2018 - ncbi.nlm.nih.gov
… One of the major obstacles to vaccine development is complex life-cycle of the parasite and
… several malaria vaccine candidates which were undergone different phase of clinical trials; …

Vaccines against malaria

A Ouattara, MB Laurens - Clinical Infectious Diseases, 2015 - academic.oup.com
… , and/or vaccine adjuvants. Here, we review the history of malaria vaccine development, then
explain the malaria life … In the first phase 3 clinical trial of a malaria vaccine, efficacy against …

The path of malaria vaccine development: challenges and perspectives

C Arama, M Troye‐Blomberg - Journal of internal medicine, 2014 - Wiley Online Library
… The main malaria vaccines currently in clinical trials are summarized in Table 1. … This
enhanced the immunogenicity of the vaccine in mice, and it is currently undergoing Phase I trials in …

Malaria vaccine developments

VS Moorthy, MF Good, AVS Hill - The lancet, 2004 - thelancet.com
… Only vaccines being tested in clinical trials as of May, 2003, are listed. Field collaborations
are … Phase-I trials of varying doses of RTS,S in children aged 1–11 years have already been …