An efficacy trial of a malaria vaccine in Gambian infants and comparison with insecticide-treated bednets

U D'Alessandro - Annals of Tropical Medicine & Parasitology, 1996 - Taylor & Francis
SPf66 has already been found to have a 31% protective efficacy in Tanzanian children
The incidence of clinical malaria was higher among children who received SPf66 than among …

A trial of the synthetic malaria vaccine SPf66 in Tanzania: rationale and design

PL Alonso, M Tanner, T Smith, RJ Hayes… - Vaccine, 1994 - Elsevier
… is to determine whether immunization with three doses of SPf66 reduces the incidence of …
to malaria or the prevalence and intensity of parasitaemia in Tanzanian children aged 1-5 years…

Vaccines for preventing malaria

PM Graves, H Gelband… - Cochrane Database …, 1996 - cochranelibrary.com
… falciparum malaria following vaccination with SPf66 in other regions. Further research with …
of the initial vaccinated group in the SPf66 Tanzania 1996 trial (48 children given vaccine and …

Evaluation of SPf66 malaria vaccine efficacy in Brazil

M Urdaneta, A Prata, CJ Struchiner, CE Tosta, P Tauil… - 1998 - arca.fiocruz.br
… randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia,
Brazil. … 0–52%) was obtained in Tanzanian children 2–5 years of age in contrast with a …

SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand

S Migasena, DG Heppner, DE Kyle… - Acta tropica, 1997 - Elsevier
children. This report describes an open label study of US SPf66 vaccine lots 13301 and 1-1-93
in 11 malaria … basis for their subsequent study in a malaria-endemic region of Thailand (…

Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization

A Bermúdez, C Reyes, F Guzmán, M Vanegas, J Rosas… - Vaccine, 2007 - Elsevier
vaccine SPf66 whilst 107 children aged 1–… Tanzania in an area of intense perennial malarial
transmission (the Kilombero valley) in children aged 1–5; 274 received 1 mg of the vaccine (…

Malaria vaccine trials: the missing qualitative data

MU Ferreira - Immunology and cell biology, 1996 - Wiley Online Library
… trials of the synthetic malaria vaccine SPf66 have shown restricted, … Most, if not all, Tanzanian
children were primed, ie had … in outcome in the Tanzanian and Gambian SPf66 trials are far …

Malaria vaccines: from the laboratory to the field

B Genton, G Corradin - Current Drug Targets-Immune …, 2002 - ingentaconnect.com
… Some reduction of malariaattributable morbidity was also observed in Tanzanian children
under … Thus, in its alum-based formulation, SPf66 does not appear to have a role in malarial

Safety, tolerability and immunogenicity of new formulations of the Plasmodium falciparum malaria peptide vaccine SPf66 combined with the immunological adjuvant …

O Kashala, R Amador, MV Valero, A Moreno… - Vaccine, 2002 - Elsevier
SPf66 is a synthetic malaria peptide vaccine, which has been … SPf66/QS-21 vaccines were
evaluated for safety, tolerability … Tanzanian children under 1 year of age [12], [13] and in older …

17 SPf66: The First and Towards the Second Generation of Malarial Vaccines

ME Patarroyo, R Amador - 1999 - api.taylorfrancis.com
… immunised with the SPf66 vaccine and challenged by … and efficacy of the SPf66 malaria
vaccine produced and formulated … in children vaccinated with SPf66 in the Tanzanian tria! could …