… macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

TW Phares, AD May, CJ Genito, NA Hoyt, FA Khan… - Malaria journal, 2017 - Springer
… for down-selecting human malaria vaccine formulations, but the … direct efficacy testing of
human malaria vaccines. Transgenic rodent … outcomes of experimental human malaria vaccines. …

Multi-functional antibody profiling for malaria vaccine development and evaluation

DH Opi, L Kurtovic, JA Chan, JL Horton… - … Review of Vaccines, 2021 - Taylor & Francis
functional effector mechanisms of antibodies against malaria and the development and
application of in vitro assays to measure these functional … targets and clinical outcomes, obscures …

Correlates of malaria vaccine efficacy

DI Stanisic, MBB McCall - Expert Review of Vaccines, 2021 - Taylor & Francis
… of a 75% effective malaria vaccine [Citation4]. Progress with malaria vaccine development
and … Moreover, outcomes may present a unidimensional impression of the immune response …

Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model

DL Guilbride, P Gawlinski, PDL Guilbride - PLoS One, 2010 - journals.plos.org
… ineffective malaria vaccines, and forces fundamental reassessment of central precepts
determining vaccine … This has major implications for accelerated local eliminations of malaria, and …

Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection

B Sack, SHI Kappe, DN Sather - Expert Review of Vaccines, 2017 - Taylor & Francis
… Introduction: An effective malaria vaccine would be considered a milestone of modern medicine,
… Since LSA1 is an antigen expressed only in late intrahepatocytic parasites, the outcome

Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
… are urgently needed to prevent the severe outcomes associated with pregnancy-associated
malaria for both mother and offspring. Further optimisation of the placental …

[HTML][HTML] Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

DA Oyong, FJ Duffy, ML Neal, Y Du, J Carnes… - PLoS …, 2023 - journals.plos.org
… anti-malaria vaccine is critically needed to prevent malaria and … To date, there is only one
malaria vaccine recommended by … , which is the RTS,S/AS01 subunit vaccine. Nonetheless, …

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

JG Beeson, L Kurtovic, C Dobaño, DH Opi… - Science translational …, 2019 - science.org
… After successful preclinical development, numerous approaches have been used to evaluate
vaccines for efficacy in clinical trials, using different outcome measures. Demonstrating …

[图书][B] Malaria vaccines: preferred product characteristics and clinical development considerations

World Health Organization - 2022 - books.google.com
… However, a healthy market of vaccinesvaccines will be vital in our efforts to reduce global
malaria burden and to achieve elimination and eradication. This includes malaria vaccines to …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
… "It has been a long way of hope for an effective malaria vaccine and now for the first time
ever, we have such a vaccine recommended for widespread use…. Today’s recommendation …