Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: In Silico Modeling Integrates Imaging and Histology

KR Swanson, RC Rockne, J Claridge, MA Chaplain… - Cancer research, 2011 - AACR
… “malignancy,” and we found that changes in the net rates of proliferation (ρ) and invasion (D)
are not always necessary for malignant progression… not required for malignant progression. …

[HTML][HTML] In silico modeling for tumor growth visualization

F Jeanquartier, C Jean-Quartier, D Cemernek… - BMC systems …, 2016 - Springer
… In silico models complement in vivo models. Research on tumor growth involves a
plethora of models each emphasizing isolated aspects of benign and malignant neoplasms. …

[HTML][HTML] In silico modeling predicts drug sensitivity of patient-derived cancer cells

SC Pingle, Z Sultana, S Pastorino, P Jiang… - Journal of translational …, 2014 - Springer
… in silico model, where we simulate GBM tumor cells using genomic profiling data. We use
this in silico tumor model … We then used the tumor model to predict sensitivity of patient-derived …

An in silico model to demonstrate the effects of Maspin on cancer cell dynamics

MA Al-Mamun, DM Farid, L Ravenhil… - Journal of theoretical …, 2016 - Elsevier
… This paper extends the previous in silico model by … Furthermore, the model concentrates
how the in silico … The data collected from in vitro and in silico experiments formulates an …

Machine Learning for In Silico Modeling of Tumor Growth

F Jeanquartier, C Jean-Quartier, M Kotlyar… - Machine Learning for …, 2016 - Springer
… aspects of the various kinds of benign and malignant neoplasms. The main challenges in …
In summary, ML can be used to improve in silico modeling, ranging from model validation to …

Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth

S Sanga, HB Frieboes, X Zheng, R Gatenby, EL Bearer… - Neuroimage, 2007 - Elsevier
… As a result, successful individualized treatment of highly malignant and invasive cancers, …
recent computational modeling efforts (eg, continuum, discrete, and cellular automata models) …

In silico models of cancer

LB Edelman, JA Eddy, ND Price - … Reviews: Systems Biology …, 2010 - Wiley Online Library
… Computational models of cancer are being developed to aid both biological discovery
and clinical medicine. The development of these in silico models is facilitated by rapidly …

[HTML][HTML] Connecting cancer pathways to tumor engines: A stratification tool for colorectal cancer combining human in vitro tissue models with boolean in silico models

F Baur, SL Nietzer, M Kunz, F Saal, J Jeromin… - Cancers, 2019 - mdpi.com
… In the last step (IV), we reflect results from 3D models by bioinformatical in silico models
that connect the two most frequently impaired common signaling pathways in this CRC …

Mathematical modeling of cancer progression and response to chemotherapy

S Sanga, JP Sinek, HB Frieboes, M Ferrari… - Expert review of …, 2006 - Taylor & Francis
… formed vasculature, a tumor may become malignant and rapidly invade local tissue, usually
… treatment, are ideal candidates for in silico (computer) modeling, which has the power to …

In Silico Modelling of Tumour Margin Diffusion and Infiltration: Review of Current Status

FL Moghaddasi, E Bezak… - … and Mathematical Methods …, 2012 - Wiley Online Library
… The in silico prediction of malignant progression of tumour corresponded well with imaging
(MRI) and histologic data of three GBM patients who had approximately similar size of tumour …