Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
NF-κB has … NF-κB activation, the role of NF-κB in tumor promotion and suppression, as well
as a few important pharmacological strategies that have been developed to modulate NF-κB

The IκB kinase complex: master regulator of NF-κB signaling

LA Solt, MJ May - Immunologic research, 2008 - Springer
… The Nuclear Factor-kappa B (NF-κB) family of transcription factors … NF-κB activity occurs
in a number of chronic inflammatory diseases and certain types of cancers making NF-κB

NF-κB in monocytes and macrophages–an inflammatory master regulator in multitalented immune cells

M Mussbacher, M Derler, J Basílio… - Frontiers in …, 2023 - frontiersin.org
… Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein …
, cytokines, transcription factors, and regulatory proteins. Since NF-κB is expressed in almost …

The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1

D Krappmann, E Wegener, Y Sunami… - … and cellular biology, 2004 - Am Soc Microbiol
… In conclusion, this study defines a novel type of cross talk between the transcription factors
of the NF-κB and AP-1 families in the innate immune reaction elicited by LPS. Through …

c-Myc and Rel/NF-κB are the two master transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells

N Faumont, S Durand-Panteix, M Schlee… - Journal of …, 2009 - Am Soc Microbiol
… LMP1 efficiently counteracts the transcriptional repression of … governed by one single
master transcriptional system that is c… main master transcriptional systems, c-Myc and Rel/NF-κB. …

RIP1's function in NF-κB activation: from master actor to onlooker

MJM Bertrand, P Vandenabeele - Cell Death & Differentiation, 2010 - nature.com
… achieved mainly by activating the NF-κB pathway, which induces the transcription of a set of
… is lethal only if the NF-κB signaling pathway is inhibited. Because NF-κB has a crucial role in …

Extensive cooperation of immune master regulators IRF3 and NFκB in RNA Pol II recruitment and pause release in human innate antiviral transcription

JE Freaney, R Kim, R Mandhana, CM Horvath - Cell reports, 2013 - cell.com
… quantitative genome-wide analysis of transcriptional regulation of the cellular antiviral response.
… and NFκB with Mediator throughout the genome and implicates additional transcription

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

B Tian, SG Widen, J Yang, TG Wood, A Kudlicki… - Journal of Biological …, 2018 - ASBMB
… the role of the transcriptional regulator NF-κB in EMT of … TGFβ) activated NF-κB/RELA
proto-oncogene, NF-κB subunit (RELA… We conclude that RELA is a master transcriptional

NF-κB and the transcriptional control of inflammation

JP Mitchell, RJ Carmody - International review of cell and molecular …, 2018 - Elsevier
… The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

SnapShot: NF-κB signaling pathways

MS Hayden, AP West, S Ghosh - Cell, 2006 - cell.com
… degradation of IκB and the release of heterodimers of the master transcription factor NF-κB. …
Transcription of p100 allows full activation of the alternate NF-κB pathway through IKKα-…