The matrix metalloproteinase inhibitor marimastat promotes neural progenitor cell differentiation into neurons by gelatinase-independent TIMP-2-dependent …

M Sinno, S Biagioni, MA Ajmone-Cat… - Stem cells and …, 2013 - liebertpub.com
… in differentiating eNP CTX into neurons, we adopted a slightly modified differentiation protocol.
… during the entire course of the differentiation protocol to increase viability of newly formed …

Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth

H Hayashita-Kinoh, H Kinoh, A Okada, K Komori, Y Itoh… - 2001 - AACR
… and migration of cells, differentiation of neuroblasts and glial cells, and … differentiating
neurons, these molecules could contribute to the recognition of target cells by migrating neurons

Effects and mechanisms of matrix metalloproteinase2 on neural differentiation of induced pluripotent stem cells

T Shu, C Liu, M Pang, J Wang, B Liu, W Zhou, X Wang… - Brain Research, 2018 - Elsevier
… the potential to differentiate into neural lineage cells. Matrix metalloproteinase 2 (MMP2), an
… hypothesized that MMP2 may promote differentiation of iPSCs into neuron-like cells through …

[PDF][PDF] Regulation of matrix metalloproteinase expression in astrocytes, microglia and neurons

PE Gottschall, S Deb - NEUROIMMUNOMODULATION-BASEL-, 1996 - researchgate.net
… role in developmental neuronal differentiation and neurite outgrowth mainly because of the
proximity of these enzymes to the growth cone [29–31]. Thus, it seems likely that neurons are …

Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines

BZ Barkho, AE Munoz, X Li, L Li, LA Cunningham… - Stem Cells, 2008 - academic.oup.com
… Furthermore, we confirmed that the DCX + neurons that migrated to the bottom chambers
of Transwells are positive for MMP-3 and MMP-9 immunoreactivity (Fig. 3F–3H). Since MMP-2 …

Role and function of matrix metalloproteinases in the differentiation and biological characterization of mesenchymal stem cells

F Mannello, GAM Tonti, GP Bagnara, S Papa - Stem Cells, 2006 - academic.oup.com
… Moreover, while the expression levels of TIMP-1, TIMP-2, and TIMP-3 were unchanged
following stem cell differentiation into neurons and glia, the high expression level of TIMP-4 in …

Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal

L Pérez-Martínez, DM Jaworski - Journal of Neuroscience, 2005 - Soc Neuroscience
… Here, we show that TIMP-2 promotes neuronal differentiation in … Strikingly, TIMP-2 exerts its
effect on neuronal differentiation via … arrest allows neurons to acquire a differentiated state by …

Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus

A Szklarczyk, J Lapinska, M Rylski… - Journal of …, 2002 - Soc Neuroscience
… In this study, we demonstrate that MMP-9 and MMP-2 are differentially expressed by
neurons and astrocytes, respectively. Kainate administration resulted in upregulation of MMP-9 …

Effect of matrix metalloproteinases inhibition on the proliferation and differentiation of HUCB-NSCs cultured in the presence of adhesive substrates

P Szymczak, L Wojcik-Stanaszek, J Sypecka… - Acta Neurobiologiae …, 2010 - ane.pl
matrix and cell adhesion molecules are particularly interesting. The matrix metalloproteinases
are … of proliferation and differentiation of stem/ progenitor cells into mature neurons. In our …

Matrix metalloproteinase-9 in glutamate-dependent adult brain function and dysfunction.

P Michaluk, L Kaczmarek - Cell Death & Differentiation, 2007 - nature.com
Matrix metalloproteinase-9 (MMP-9) is extracellularly operating protease that is expressed
by the adult brain neurons … inhibited by tissue inhibitors of matrix metalloproteinases (TIMPs). …