[HTML][HTML] Role of matrix metalloproteinases in myelin abnormalities and mechanical allodynia in rodents with diabetic neuropathy

X Deng, P Ma, M Wu, H Liao, XJ Song - Aging and disease, 2021 - ncbi.nlm.nih.gov
… In addition, this study also showed that α-LA could attenuate mechanical allodynia in WT
mice but not produce further inhibition of mechanical allodynia in MMP-9 -/- mice, which …

Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats

M Osikowicz, G Longo, S Allard, AC Cuello… - Molecular …, 2013 - journals.sagepub.com
… In this study, we investigated whether the inhibition of mature NGF degradation, using a
matrix metalloproteinase 2 and 9 (MMP-2/9) inhibitor, was sufficient to reproduce a similar …

[HTML][HTML] Absence of mechanical allodynia and Aβ-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase

K Komori, T Nonaka, A Okada, H Kinoh… - FEBS letters, 2004 - Elsevier
Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade extracellular
matrix … did not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, …

Matrix metalloprotease regulation of neuropathic pain

RR Ji, ZZ Xu, X Wang, EH Lo - Trends in pharmacological sciences, 2009 - cell.com
… (increased responsiveness to noxious stimuli) to mechanical and cold stimuli. In particular,
mechanical allodynia or tactile allodynia (ie painful responses to normally innocuous tactile …

Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain

S Hong, AG Remacle, SA Shiryaev, W Choi… - Brain, behavior, and …, 2017 - Elsevier
… Among such myelin-related changes contributing to mechanical allodynia we proposed
is liberation of myelin auto-antigens, such as myelin basic protein (MBP), leading to the …

Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase‐9/2 in mice

Y Fan, L Hu, S Zhu, Y Han, W Liu… - European Journal of …, 2018 - Wiley Online Library
… 3.1 Paeoniflorin markedly inhibited plantar incision-induced mechanical allodynia Our
results demonstrated that plantar incision resulted in mechanical allodynia which persisted for …

NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and-9

L Kular, C Rivat, B Lelongt, C Calmel, M Laurent… - Journal of …, 2012 - Springer
… the mechanical allodynia of CFA rats treated with NOV. As shown in Figure 9E, intrathecal
delivery of siNOV resulted in a significant increase of mechanical allodynia compared to rats …

Perineural expression of high‐mobility group box‐1 contributes to long‐lasting mechanical hypersensitivity via matrix metalloprotease‐9 up‐regulation in mice with …

FF Zhang, N Morioka, S Harano… - Journal of …, 2016 - Wiley Online Library
… with anti-HMGB1 antibody significantly ameliorates nerve injury-induced mechanical
hypersensitivity, and suppresses expression of matrix metalloprotease-9 (MMP-9). The findings …

Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2

C Pan, C Wang, L Zhang, L Song, Y Chen, B Liu… - Journal of …, 2018 - Springer
… (CCI)-induced activation of matrix metalloproteinase (MMP)-9 and MMP-2. a Mechanical
allodynia was significantly induced after CCI surgery. Mechanical pain threshold was tested by …

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage

H Kobayashi, S Chattopadhyay, K Kato… - Molecular and Cellular …, 2008 - Elsevier
Matrix metalloproteinases (MMPs) emerge as modulators of … mechanical stimuli (or
mechanical allodynia), we analyzed the role of MMPs in the development of mechanical allodynia