Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

ZZ Xu, YH Kim, S Bang, Y Zhang, T Berta, F Wang… - Nature medicine, 2015 - nature.com
… ) are dispensable for the development of chemotherapy-induced mechanical allodynia 2
, we hypothesized that -fiber blockade would inhibit chemotherapy-induced …

Peripheral and spinal circuits involved in mechanical allodynia

A Arcourt, SG Lechner - Pain, 2015 - journals.lww.com
… form the cellular basis of mechanical allodynia. A role of fibers in allodynia was originally
proposed by human studies showing that compression block of fibers abolishes touch-…

-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals

L Djouhri, SN Lawson - Brain research reviews, 2004 - Elsevier
… , the possibility has not been excluded that a slight lowering of threshold and/or increase
in firing frequency in moderate pressure receptors may play a role in mechanical allodynia. …

[HTML][HTML] Absence of mechanical allodynia and -fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase

K Komori, T Nonaka, A Okada, H Kinoh… - FEBS letters, 2004 - Elsevier
… the myelinated -fiber primary … -fibers were observed in MT5-MMP-deficient mice.
These findings suggest that MT5-MMP is essential for the development of mechanical allodynia

Dynamic mechanical allodynia in humans is not mediated by a central presynaptic interaction of -mechanoreceptive and nociceptive C-afferents

G Wasner, R Baron, W Jänig - Pain, 1999 - journals.lww.com
… of -fibres in allodynic skin does not induce antidromic vasodilatation. Consequently,
interaction of -mechanoreceptive fibres and nociceptive C-fibres at a … of mechanical allodynia. …

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

Y Lu, H Dong, Y Gao, Y Gong, Y Ren… - The Journal of …, 2013 - Am Soc Clin Investig
… of most nociceptors and some mechanoreceptors innervate the superficial laminae I and II
(7–11), whereas touch-sensing, heavily myelinated fibers of mechanoreceptors terminate …

New approach for investigating neuropathic allodynia by optogenetics

M Tsuda - Pain, 2019 - journals.lww.com
… As LTMRs, including fibers, detect innocuous mechanical stimuli to the skin, it has long …
of fibers evokes mechanical allodynia. However, the necessity and sufficiency of fibers (…

Synaptic dynamics of the feed-forward inhibitory circuitry gating mechanical allodynia in mice

Q Wang, X Zhang, X He, S Du, Z Jiang, P Liu, L Qi… - …, 2020 - pubs.asahq.org
fiber stimulation evoked a biphasic synaptic response in 42% (31 of 73) of protein kinase
C γ expressing neurons. The inhibitory components of the biphasic synaptic response were …

Identification of the sensory nerve fiber responsible for lysophosphatidic acid-induced allodynia in mice

M Ohsawa, Y Miyabe, H Katsu, S Yamamoto, H Ono - Neuroscience, 2013 - Elsevier
… The present study was designed to identify the primary afferent fibers (, Aδ, or C) participating
in LPA-induced allodynia in ddY mice. Mechanical allodynia and thermal hyperalgesia …

Morphine inhibits herpetic allodynia through μ-opioid receptors induced in -fiber neurons

A Sasaki, Y Nakashima, I Takasaki, T Andoh… - …, 2008 - journals.lww.com
mechanical allodynia in mice with herpetic pain. Mechanical allodynia is mainly mediated
by fibers, whereas μ-opioid receptors are present in C and Aδ fibers. This study was …