… transporter-enzyme interplay in the hepatic disposition of drugs are reviewed, and the utility
of integrated mechanistic models … of the mechanistic understanding of the role of transporters …

… We recently presented a static mechanistic model to predict the extent of renal DDI utilizing
the in vitro data [100], which may be integrated (Eq. 8) with the change in CL H to predict the …

… It is evident that DDIs involving hepatic transporters are capable of … Areas covered: The role
of hepatic uptake transporters in … Mechanistic models that account for individual transporters …

… The major hepatic transporters involved in hepatic drug … Nevertheless, the mechanism
ultimately responsible for the … The mechanism was attributed to an inhibition of OATP1B1 …

… Based on the proteomics data from the current study, hepatic transporter abundance
difference is captured as a relative factor (ratio of abundance in steatois/NASH to normal tissues). …

… Kinetic parameters describing hepatic uptake in hepatocytes are frequently estimated … , with
telmisartan and valsartan showing the highest affinity for uptake transporters (K m,u <10 μM). …

… to measure hepatic transporter activity in health and disease. We cover mathematical modeling
… of PET to study hepatic membrane transporter activity is the mechanistic assessment of …

… Using pitavastatin as a model uptake transporter substrate, we investigated the utility of the
… and mechanistic modeling to estimate f t in hepatocytes. The transporters evaluated were …

… mechanistic model to estimate the impact of liver cirrhosis on human pharmacokinetics of
liver transporter … -1 and type-2 uptake transporters responsible for the hepatic uptake of these …

… Although the reasons for discrepancy are not completely understood, this study highlights
the need for mechanistic modeling approaches to enable translation of magnitude of …