Developing and maintaining protective CD8+ memory T cells

MA Williams, BJ Holmes, JC Sun… - Immunological …, 2006 - Wiley Online Library
… a role for CD4 + T cells in maintaining the ability of CD8 + memory T cells to respond to …
recruited CD8 + T cells, we also demonstrate that the programming of effector and memory

Principles of memory CD8 T-cells generation in relation to protective immunity

M Zanetti, P Castiglioni, E Ingulli - Memory T cells, 2010 - Springer
… is that protective T-cell responses correlate positively with the T cells of the central memory
… In proposing a set of working principles to enable protective memory T cells by vaccination …

The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells

SE Hamilton, MC Wolkers, SP Schoenberger… - Nature …, 2006 - nature.com
… can also offer protection against pathogens. Here we … memory (HP-memory) CD8 + T cells
controlled bacterial infection as effectively as 'true' memory CD8 + T cells, but their protective

[HTML][HTML] Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection

JC Nolz, JT Harty - Immunity, 2011 - cell.com
… , we also compared the protective capacity of memory CD8 + T cells by using three other
acute infection models. Indeed, secondary memory CD8 + T cells were also better at reducing …

Lineage relationship and protective immunity of memory CD8 T cell subsets

EJ Wherry, V Teichgräber, TC Becker, D Masopust… - Nature …, 2003 - nature.com
… Two subsets of memory T cells were described based on their … Memory T cells that express
molecules such as CD62L and … central memory cells (T CM ), whereas memory T cells that …

Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells

JC Sun, MJ Bevan - The Journal of Immunology, 2004 - journals.aai.org
… the number of memory CD8 T cells generated in … protective memory and CD8 T cell
secondary responses are the same whether or not CD40 is present on either APCs or CD8 T cells

Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection

T Wu, Y Hu, YT Lee, KR Bouchard… - Journal of leukocyte …, 2014 - academic.oup.com
… As the goal of the study was to image virus-specific memory CD8 T cells in the lungs during
a protective CTL response, we used naive OTI cells to generate traceable populations of …

[HTML][HTML] Effector-like CD8+ T cells in the memory population mediate potent protective immunity

JA Olson, C McDonald-Hyman, SC Jameson… - Immunity, 2013 - cell.com
… division scheme for CD8 + memory T cells is the paradigm of central and effector memory
cells, based on CD62L and CCR7 expression. Central memory T (Tcm) cells, which express …

Resident-memory CD8 T cells and mTOR: generation, protection, and clinical importance

RT Sowell, AL Marzo - Frontiers in Immunology, 2015 - frontiersin.org
T CM /T EM paradigm. Through the study of circulating CD8 T cells, our understanding of
memory CD8 T cells … of circulating memory CD8 T cells in order to enhance protection against …

Secondary memory CD8+ T cells are more protective but slower to acquire a central–memory phenotype

A Jabbari, JT Harty - The Journal of experimental medicine, 2006 - rupress.org
CD8 T cell memory. Here, we show that, compared with primary memory CD8 T cells,
secondary memory CD8 T cells exhibit substantially delayed conversion to a central–memory