Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV

S Aherfi, B Pradines, C Devaux, S Honore… - Future …, 2021 - Taylor & Francis
… In the context of health emergency, drug repurposing represents the most relevant strategy …
such drugs. Herein, we aim to review drugs with in vitro antiviral activity against SARS-CoV-2, …

Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing

P Krishnamoorthy, AS Raj, S Roy, NS Kumar… - Computers in biology …, 2021 - Elsevier
… For MERS-CoV transcriptome data, we queried the GEO database with the terms “MERS
CoV”, “MERS CoV AND Homo sapiens”. We screened the datasets in such a way that the …

[HTML][HTML] Strategies for drug repurposing against coronavirus targets

PO Smith, P Jin, KM Rahman - … Research in Pharmacology and Drug …, 2022 - Elsevier
drug repurposing in the context of human coronaviruses, SARS-CoV, MERS-CoV, and, in
particular, SARS-CoV-2, the virus … a focus on the strategy by which the drugs were repurposed. …

Perspectives for repurposing drugs for the coronavirus disease 2019

SS Cherian, M Agrawal, A Basu… - Indian Journal of …, 2020 - journals.lww.com
… Here we summarize the present status of both virus-based and host-based drug
repurposing perspectives for coronaviruses in general and the SARS-CoV-2 in particular. …

Identification of doxorubicin as repurposing inhibitory drug for MERS-CoV PLpro

AL Alaofi, M Shahid, M Raish, MA Ansari, R Syed… - Molecules, 2022 - mdpi.com
… , and G276 of MERS-CoV PLpro. Development of drug repurposing is a remarkable opportunity
to … Protease inhibitors have been found to be effective against MERS-CoV to date, and …

[HTML][HTML] Drug repurposing against MERS CoV and SARS-COV-2 PLpro in silico

A Elfiky, N Ibrahim, W Elshemey - 2020 - europepmc.org
… -SARS CoV and anti-HCV NS3 drugs to inhibit MERS CoV PL pro … drug repurposing is
performed to test anti-HCV and anti-SARS drugs against the Papain-like proteases of MERS CoV

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

CZ Chen, M Xu, M Pradhan, K Gorshkov… - ACS Pharmacology & …, 2020 - ACS Publications
drug repurposing screens using SARS-S and MERS-S PP entry assays to identify a set of
broad-spectrum coronavirus … as the CPE assay, but without the addition of SARS-CoV-2 virus. …

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Y Zhou, Y Hou, J Shen, Y Huang, W Martin, F Cheng - Cell discovery, 2020 - nature.com
… to de novo drug discovery. In this study, we present an integrative, antiviral drug
repurposing … between the HCoV–host interactome and drug targets in the human protein–protein …

Drug repurposing approach to fight COVID-19

TU Singh, S Parida, MC Lingaraju, M Kesavan… - Pharmacological …, 2020 - Springer
… and it is considered as a very effective strategy for drug discovery as it … novo drug discovery
process. The present review will focus on the repurposing efficacy of the currently used drugs

[HTML][HTML] Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigations

SE Omer, TM Ibrahim, OA Krar, AM Ali, AA Makki… - … and biophysics reports, 2022 - Elsevier
Drug repurposing is the most recent technique. The term “drug repurposing” refers to the
process of repurposing existing … Drug repurposing has long been recognized as a precise …