Q Wang, G Wong, G Lu, J Yan, GF Gao - Antiviral research, 2016 - Elsevier
… The MERS-CoVspike (S) protein is an … of the S protein in the MERS-CoV life cycle, summarize recent advances in the development of vaccines and therapeutics based on the S protein, …
Y Zhou, S Jiang, L Du - Expert review of vaccines, 2018 - Taylor & Francis
… mortality rate in humans, no vaccines have been approved to prevent MERS-CoV infection in humans. MERS-CoVspike (S) protein is a key target for development of MERS vaccines. …
S Xia, Q Liu, Q Wang, Z Sun, S Su, L Du, T Ying, L Lu… - Virus research, 2014 - Elsevier
… MERS-CoV infection. Here we discuss the most recent studies on the structure of … MERS-CoV spikeprotein and its role in virus binding and entry, and the development of MERS-CoV …
… spike (S) protein plays an important role in the evolution and transmission of SARS-CoV-2. So far, studies have shown that various genes encoding primarily for elements of S protein …
H Kleine-Weber, MT Elzayat, M Hoffmann… - Scientific reports, 2018 - nature.com
… novel antiviral strategies to combat MERS. The MERS-CoVspikeprotein (MERS-S) is inserted into the viral envelope and mediates viral entry into target cells. For this, MERS-S binds to …
G Lu, Q Wang, GF Gao - Trends in microbiology, 2015 - cell.com
… Figure 1Severe acute respiratory syndrome coronavirus (SARS-CoV) spike features. (A) Schematic representation of the SARS-CoVspikeprotein (S). The individual components of S …
L Du, Z Kou, C Ma, X Tao, L Wang, G Zhao, Y Chen… - PloS one, 2013 - journals.plos.org
… halt the spread of MERS-CoV. Here, we show that a recombinant protein containing a 212-… (RBD: residues 367–606) of MERS-CoVspike (S) protein fused with human IgG Fc fragment (…
N Wang, X Shi, L Jiang, S Zhang, D Wang, P Tong… - Cell research, 2013 - nature.com
… RBD and DPP4, we generated a series of mutant MERS-CoV RBD proteins and characterized their impact on binding activity to DPP4 and the entry efficiency of pseudotyped viruses …
… To improve the expression and conformational homogeneity of the prefusion MERS-CoV S protein ectodomain we engineered variants based upon our previously determined structure …