Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
… The term ‘cytokine storm syndrome’ is perhaps one of the critical hallmarks of COVID-19
In this review, we highlight prominent cytokine families and their potential role in COVID-19, the …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
… this cytokine storm is responsible for the multiorgan damage observed in patients with
severe COVID-19 [2]. A number of immunomodulatory therapies targeting these cytokines have …

Identification of parameters representative of immune dysfunction in patients with severe and fatal COVID-19 infection: a systematic review and meta-analysis

R Qin, L He, Z Yang, N Jia, R Chen, J Xie, W Fu… - Clinical Reviews in …, 2023 - Springer
… The currently updated meta-analysis primarily identified a hypercytokinemia profile with the
severity and mortality of COVID-19 containing IL-1β, IL-1Ra, IL-2R, IL-4, IL-6, IL-8, IL-10, IL-…

[PDF][PDF] IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression

SK Dhar, K Vishnupriyan, S Damodar, S Gujar, M Das - Heliyon, 2021 - cell.com
… Exuberant inflammation manifested as elevated levels of cytokines, commonly referred as
cytokine storm” (CS) often leads to critical conditions like ARDS (acute respiratory distress …

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, CC Bortolasci, BK Puri, W Marx, A O'Neil… - Cytokine, 2021 - Elsevier
… or even harmful as far as COVID-19 patients are concerned. Hence, this paper aims to
compare the mechanisms involved in the generation of cytokine storms in each of the conditions …

[HTML][HTML] Association of inflammatory markers with the severity of COVID-19: A meta-analysis

F Zeng, Y Huang, Y Guo, M Yin, X Chen, L Xiao… - International Journal of …, 2020 - Elsevier
… In our meta-analysis, severe or critical COVID-19 patients were grouped into the severe group,
and mild or moderate COVID-19 … Our study firstly put forward that in addition to IL-6, other …

Pathogenesis and treatment of cytokine storm in COVID-19

M Soy, G Keser, MP Atagündüz - Turkish Journal of Biology, 2021 - journals.tubitak.gov.tr
metaanalysis of clinical trials of critically ill patients with … in COVID-19, this study also supports
the possible benefit of anti-TNF agents in the treatment of the cytokine storm of COVID-19. …

Preliminary predictive criteria for COVID-19 cytokine storm

R Caricchio, M Gallucci, C Dass, X Zhang… - Annals of the …, 2021 - ard.bmj.com
Objectives To develop predictive criteria for COVID-19-associated cytokine storm (CS), a
severe hyperimmune response that results in organ damage in some patients infected with …

[HTML][HTML] Profile of circulatory cytokines and chemokines in human coronaviruses: a systematic review and meta-analysis

A Zawawi, AY Naser, H Alwafi, F Minshawi - Frontiers in Immunology, 2021 - frontiersin.org
… Evidence suggests that the considerable elevation of IL-6 cytokines in severe COVID-19
the onset of a cytokine storm could be detrimental for the host during COVID-19 infection. For …

Efficacy and safety of IL-6 inhibitors in patients with COVID-19 pneumonia: a systematic review and meta-analysis of multicentre, randomized trials

A Belletti, C Campochiaro, M Marmiere… - Annals of Intensive …, 2021 - Springer
… -6 (IL-6) is involved in COVID-19-associated cytokine storm, and several trials investigated
whether its inhibition could improve patients’ outcome. We performed a meta-analysis of …