… a disease in which pancreatic beta-cell dysfunction is a critical element, obesity is a condition
in which inherent genetic … as a metabolic disease (although it can have grave metabolic …

… Historically, human genetics has been dominated by two models—monogenic and
polygenic—which mapped onto the approaches used for risk-variant detection (family based versus …

… in human genetics for the coming years is to develop a deep understanding of the genetic
basis of metabolic disease by: (i) synthesizing a comprehensive set of the genes and proteins …

… that common variants in a number of genes will increase susceptibility to the metabolic
syndrome and that these genes will act in concert with a number of environmental factors. …

… the extent to which human genetic data are incorporated into studies that hypothesize novel
links between genes and metabolic disease. To lower the barriers to using genetic data, we …

… , Parkinson disease, Huntington disease, and other diseases; and (c) … " diseases today. To
test the hypothesis that common mtDNA variation influences human physiology and disease, …

… and rare mutations of the human adiponectin gene itself were … human genetic studies on
adiponectin and the metabolic … insights into the genetic makeup of the metabolic syndrome. …

… approach to inherited metabolic diseases should help col… For metabolic and genetic
specialists, this book is designed … and clinical symptomatology in metabolic disease. It outlines the …

… Diseases that affect the development and function of the embryo, fetus and infant. This …
of Metabolic Diseases has been expanded to include the advances in molecular and genetic …

… To test whether VAT mass was associated with cardiovascular and metabolic disease, we
performed logistic regression using VAT^ as the predictor variable and disease status as the …