NLRP3 inflammasome in cancer and metabolic diseases

BR Sharma, TD Kanneganti - Nature immunology, 2021 - nature.com
… Therefore, fine tuning of NLRP3 inflammasome activity is essential for … NLRP3 inflammasome
activation and its divergent roles in the pathogenesis of inflammation-associated diseases

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

H Wen, JPY Ting, LAJ O'neill - Nature immunology, 2012 - nature.com
NLRP3 inflammasome and the metabolism of lipids and carbohydrates. This occurs at the
level of enhanced NLRP3 inflammasome … also at the level of glucose metabolism through the …

NLRP3 inflammasome activation in adipose tissues and its implications on metabolic diseases

KKL Wu, SWM Cheung, KKY Cheng - International Journal of Molecular …, 2020 - mdpi.com
metabolic disorders. In this review, we summarize both the negative and positive regulators
of NLRP3 inflammasome … tissue inflammasome for the treatment of obesity and its related …

The NLRP3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders

E Benetti, F Chiazza, NSA Patel… - Mediators of …, 2013 - Wiley Online Library
… the effects of the NLRP3 inflammasome activation in the complex … metabolic disease
pathogenesis. We will provide here a perspective on the current research on NLRP3 inflammasome

The NLRP3 inflammasome: role in metabolic disorders and regulation by metabolic pathways

D Jiang, S Chen, R Sun, X Zhang, D Wang - Cancer letters, 2018 - Elsevier
… 6), are closely associated with the pathogenesis of various metabolic diseases [37]. In
this complicated process, the NLRP3 inflammasome acts as a sensor for many obesity-associated …

Focus on the Role of NLRP3 Inflammasome in Diseases

R Fusco, R Siracusa, T Genovese… - International journal of …, 2020 - mdpi.com
… acids trigger inflammasome activation, which harms glucose metabolism and … metabolic
diseases, the accumulation of abnormal metabolic products activates the NLRP3 inflammasome

The roles of the NLRP3 inflammasome in neurodegenerative and metabolic diseases and in relevant advanced therapeutic interventions

RH Pirzada, N Javaid, S Choi - Genes, 2020 - mdpi.com
… neurodegenerative and metabolic disorders including Alzheimer’s disease, multiple …
targeting to the NLRP3 inflammasome complex is a promising way to treat these diseases. Recent …

Role of NLRP3 inflammasome activation in obesity-mediated metabolic disorders

K Wani, H AlHarthi, A Alghamdi, S Sabico… - International journal of …, 2021 - mdpi.com
… Understanding the mechanisms involved in the regulation of NLRP3 inflammasome in …
metabolic diseases. In this narrative review, the current understanding of NLRP3 inflammasome

The NLRP3 inflammasome: metabolic regulation and contribution to inflammaging

AK Meyers, X Zhu - Cells, 2020 - mdpi.com
NLRP3 inflammasome in metabolic diseases such as atherosclerosis and type 2 diabetes
[60,61]. Interestingly, the NLRP3 inflammasome … that the inflammasome and autophagosomes …

Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders

T Ji, Y Han, W Yang, B Xu, M Sun… - Journal of cellular …, 2019 - Wiley Online Library
… member of the NLR family of inflammasomes to date. ERS intersects … the NLRP3
inflammasome. In this review, we focus on the interactions between ERS and the NLRP3