… therapy or maintenance therapy. We review the latest clinical trials of metronomic chemotherapy
in … need to be made to facilitate the optimal development of metronomic chemotherapy. …

… leads to sustained plasma concentration of the drug but rise and fall of the plasma
concentration is the feature of conventional therapy • Metronomic therapy is targeted to endothelial …

… chemotherapy doses, editorials and review articles. An additional PubMed search using the
term ‘metronomic chemotherapy… the addition of LDM chemotherapy to targeted therapy (n = 2…

… other experimental therapy, metronomic chemotherapy (MCT… the experimental field of
metronomic chemotherapy, plus the … change in the design of therapeutic protocols against cancer. …

… However, the low cost, ease of administration, and acceptable toxicity profiles potentially
associated with this therapeutic strategy make metronomic chemotherapy protocols attractive …

… Other authors have shown that metronomic chemo-endocrine therapy leads to a higher
expression of autophagy-related proteins, beclin 1 and LC3, and apoptosis-related markers …

… with conventional maximum tolerated dose chemotherapy. Good … prefer oral therapy and
metronomic chemotherapy is a … metronomic chemotherapy compared with no further therapy …

… By reviewing the mechanisms of action of metronomic chemotherapy in this paper … -dose
frequent chemotherapy in facilitating the recent shift in clinical oncology from cytotoxic therapies …

… Therefore, introducing break periods in long-term therapies such as metronomic chemotherapy
may increase treatment efficacy by killing dependent (and the most resistant) cancer …

… Oversimplifying, it is retained that MTD regimens act on tumour cells, while metronomic
or “high-time” therapies exert most of their effects on endothelial cells. An interesting work …