miR-192 enhances sensitivity of methotrexate drug to MG-63 osteosarcoma cancer cells
M Bazavar, J Fazli, A Valizadeh, B Ma… - … -Research and Practice, 2020 - Elsevier
Chemo-resistance remains a considerable obstacle encountered in osteosarcoma (OS)
therapy. Evidence has implied that a reduction in the expression of microRNAs
(miRs/miRNAs) leads to exacerbated chemo-resistance. Hence, to better understand the
role of miR-192 in the pathogenesis of OS during methotrexate (MTX) treatment, we restore
miR-192 in the MG-63 cells and investigate the mechanisms, which are associated with MTX-
resistance in OS. Exogenetic overexpression of miR-192 was established by transfecting …
therapy. Evidence has implied that a reduction in the expression of microRNAs
(miRs/miRNAs) leads to exacerbated chemo-resistance. Hence, to better understand the
role of miR-192 in the pathogenesis of OS during methotrexate (MTX) treatment, we restore
miR-192 in the MG-63 cells and investigate the mechanisms, which are associated with MTX-
resistance in OS. Exogenetic overexpression of miR-192 was established by transfecting …
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