Microglial activation and matrix protease generation during focal cerebral ischemia

GJ del Zoppo, R Milner, T Mabuchi, S Hung, X Wang… - Stroke, 2007 - Am Heart Assoc
… The association of cerebral microglial cell reactivity and MMP (gelatinase) generation in the
setting of focal cerebral ischemia suggests the question of how microglial activation can alter …

[HTML][HTML] Microglial activation in stroke: therapeutic targets

MA Yenari, TM Kauppinen, RA Swanson - Neurotherapeutics, 2010 - Elsevier
Microglial activation is an early response to brain ischemia and many other stressors.
MicrogliaMicroglial responses to cerebral ischemia can be conceptualized in terms of three …

Microglia in cerebral ischemia: molecular actions and interactions

AY Lai, KG Todd - Canadian journal of physiology and …, 2006 - cdnsciencepub.com
… Thus, microglial activation in cerebral ischemia may not always be harmful. It is likely that
the nature and extent of neuronal injury are important factors that dictate how …

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

J Yrjänheikki, R Keinänen, M Pellikka… - Proceedings of the …, 1998 - National Acad Sciences
microglial activation and ICE induction are inhibited by minocycline. Mature IL-1β is secreted
by activated microglia … by disrupting the blood–brain barrier and recruiting neutrophils (44–…

Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice

K Rupalla, PR Allegrini, D Sauer, C Wiessner - Acta neuropathologica, 1998 - Springer
… cerebral ischemia. To asses this assumption further, we investigated the temporal course
of microglia activation after focal cerebral ischemia in the primary ischemic lesion area and in …

Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone …

M Schilling, M Besselmann, C Leonhard… - Experimental …, 2003 - Elsevier
… deficient in the microglial growth factor … microglial response to focal cerebral ischemia and
an increase in infarct size, suggesting a protective role of microglial cells in ischemic stroke (…

Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats

CL Hsieh, CY Cheng, TH Tsai, I Lin, CH Liu… - Journal of …, 2006 - Elsevier
… We used the percentage of cerebral infarction area to total brain area in each piece of brain
tissue and neuro-deficit score as an index to evaluate the effect of Paeonol on the cerebral

MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

J Ni, X Wang, S Chen, H Liu, Y Wang, X Xu… - Brain, behavior, and …, 2015 - Elsevier
microglial activity. The present study revealed that suppression of microglia activation by
let-7c-5p overexpression may be involved in the protection effects of ischemic damage. …

Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia–reperfusion injury

S Zhao, J Yin, L Zhou, F Yan, Q He, L Huang… - Brain, Behavior, and …, 2016 - Elsevier
brain ischemia-induced microglial activation in vitro, we adopt the oxygen glucose deprivation
(OGD) model to stimulate microglia and assess the role of MST1 in microglial activation. …

Role of microglia under cardiac and cerebral ischemia/reperfusion (I/R) injury

P Surinkaew, P Sawaddiruk, N Apaijai… - Metabolic brain …, 2018 - Springer
… Therefore, the present review summarized and discussed those studies regarding the
effects of global and focal cerebral as well as cardiac I/R injury on microglia activation, and the …