Sarcolemmal and mitochondrial KATP channels and myocardial ischemic preconditioning

JN Peart, GJ Gross - Journal of cellular and molecular …, 2002 - Wiley Online Library
… the sarcKATP or the mitoKATP channel as either triggers and/… from the sarcKATP channel
to the mitoKATP channel as a … of APD as a result of sarcKATP channel activation was not the …

Ischemic preconditioning requires increases in reactive oxygen release independent of mitochondrial K+ channel activity

HTF Facundo, RS Carreira, JG de Paula… - Free Radical Biology …, 2006 - Elsevier
… of these channels during preconditioning. We found no evidence that mitoK ATP channels
… In addition, neither ischemic preconditioning nor the mitoK ATP agonist diazoxide increased …

Signaling Mechanisms in Ischemic Preconditioning: Interaction of PKCε and MitoKATP in the Inner Membrane of Mitochondria

H Ardehali - Circulation research, 2006 - Am Heart Assoc
… a mitochondrial channel, called the mitochondrial ATP-sensitive potassium channel or mitoK
… of IPC; drugs that activate this channel protect against ischemia and inhibitors of mitoK ATP …

Differential role of sarcolemmal and mitochondrial KATP channels in adenosine-enhanced ischemic preconditioning

Y Toyoda, I Friehs, RA Parker… - American Journal of …, 2000 - journals.physiology.org
ischemic preconditioning (APC) extends the protection afforded by ischemic preconditioning
(IPC) … potassium (K ATP ) channels and to determine whether this modulation occurs before …

KATP channels and myocardial preconditioning: an update

GJ Gross, JN Peart - American Journal of Physiology-Heart …, 2003 - journals.physiology.org
… Furthermore, the K ATP channel has been demonstrated to play a central role in the
phenomenon termed ischemic preconditioning (IPC). Structurally, K ATP channels are composed of …

Ischemic preconditioning in rats: role of mitochondrial KATP channel in preservation of mitochondrial function

RM Fryer, JT Eells, AK Hsu… - American Journal of …, 2000 - journals.physiology.org
… We examined the role of the sarcolemmal and mitochondrial K ATP channels in a rat model
of ischemic preconditioning (IPC). Infarct size was expressed as a percentage of the area at …

Role of mitochondrial KATP channels and protein kinase C in ischaemic preconditioning

Y Uchiyama, H Otani, M Wakeno… - Clinical and …, 2003 - Wiley Online Library
… Diazoxide was administered for 15 min before index ischaemia in the presence or absence
of the mitoK ATP channel inhibitor 5-HD. Ischaemic preconditioning was introduced by three …

Evidence for mitochondrial KATP channels as effectors of human myocardial preconditioning

S Ghosh, NB Standen, M Galinanes - Cardiovascular Research, 2000 - academic.oup.com
… K ATP channels. The present study provides evidence for the first time that mitoK ATP
channels may be the effectors of ischemic preconditioning in the human myocardium. …

Myocardial KATP Channels in Preconditioning

B O'Rourke - Circulation research, 2000 - Am Heart Assoc
… More recently, the discovery of the endogenous cellular protective mechanism known as
ischemic preconditioning (IPC) has raised hopes that natural pathways or target proteins could …

… mitochondrial permeability transition pore and mitochondrial ATP-sensitive potassium channels in the protective effects of ischemic preconditioning in isolated hearts …

MG Marina Prendes, R Hermann, ME Torresin… - Journal of physiology …, 2014 - Springer
… assess whether the protective effects of ischemic preconditioning (PC) are associated with
channels (mitoKATP) and if there is any relationship between the activity of these channels