Experimental models of Parkinson's disease

MF Beal - Nature reviews neuroscience, 2001 - nature.com
… α-synuclein mutations as a rare cause of Parkinson's disease has led to the development of
α-… animal models in our attempts to understand the physiology of Parkinson's disease and to …

Animal models of Parkinson's disease

V Jackson-Lewis, J Blesa, S Przedborski - Parkinsonism & related disorders, 2012 - Elsevier
models parallel our thinking about the etiology of PD. Thus, herein, we discuss the most
popular neurotoxin animal models, 6-… common genetic rodent models of PD. None of the above …

Disease model: Parkinson's disease

S Shimohama, H Sawada, Y Kitamura… - Trends in molecular …, 2003 - cell.com
disease models. In this review, we summarize the available in vivo and in vitro models of
PD and discuss their value. Parkinson's disease (PD) is an age-related neurodegenerative …

The MPTP model of Parkinson's disease

RJ Smeyne, V Jackson-Lewis - Molecular brain research, 2005 - Elsevier
… of useful animal models of Parkinson's disease. In mice, … of substantia nigra neurons in
Parkinson's disease may result from a … understanding of idiopathic Parkinson's disease as well as …

Models of Parkinson's disease

M Orth, SJ Tabrizi - Movement Disorders, 2003 - Wiley Online Library
… symptoms but cannot stop disease progression.17 Disease models help further our understanding
… level, and thus these models aid the development of therapeutic strategies. Ideally, a …

Protocol for the MPTP mouse model of Parkinson's disease

V Jackson-Lewis, S Przedborski - Nature protocols, 2007 - nature.com
… of producing a reliable mouse model of Parkinson's disease (PD) using … model, provide
key references and outline what investigators need to know to develop the MPTP mouse model

Evaluation of models of Parkinson's disease

SA Jagmag, N Tripathi, SD Shukla, S Maiti… - Frontiers in …, 2016 - frontiersin.org
Parkinson's disease is one of the most common neurodegenerative diseases. Animal
models have contributed a large part to our understanding and therapeutics developed for …

Historical perspective: models of Parkinson's disease

SJ Chia, EK Tan, YX Chao - International journal of molecular sciences, 2020 - mdpi.com
… The disease model can be generated through neurotoxin-based … Cellular-based disease
model is frequently used because of … PD models and their utility for different research purposes. …

Toxin-induced models of Parkinson's disease

J Bové, D Prou, C Perier, S Przedborski - NeuroRx, 2005 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease that appears essentially …
come from investigations performed in experimental models of PD, especially those …

Animal models of Parkinson's disease

R Betarbet, TB Sherer, JT Greenamyre - Bioessays, 2002 - Wiley Online Library
… and clinical findings, Parkinson's disease PD) was the first neurological disease to be modeled
and, … animal models of PD and compares them with characteristics of the human disease. …