Sunitinib-induced asthenia: from molecular basis to clinical relief

LMA Aparicio, EG Pulido, GA Gallego - Cancer biology & therapy, 2011 - Taylor & Francis
… deeper understanding of the molecular basis and mechanisms of action of antitumor agents
to clinically manage adverse events. Considering different clinical observations and current …

The molecular basis of pain and its clinical implications in rheumatology

B Bingham, SK Ajit, DR Blake, TA Samad - Nature clinical practice …, 2009 - nature.com
molecular targets discussed in this Review are still in clinical or preclinical stages of
development. If trials are successful, clinicians … pain relief that is free from debilitating side effects. …

The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis

F Buttgereit, KG Saag, M Cutolo… - Scandinavian journal …, 2005 - Taylor & Francis
… GC resistance in RA is not well defined; for daily practice waning of symptomatic relief is
considered to be a sign of GC resistance. By this definition, over 30% of patients with RA …

Molecular basis for treating endometriosis with aromatase inhibitors

SE Bulun, KM Zeitoun, K Takayama… - Human Reproduction …, 2000 - academic.oup.com
Although treatment of one unusually aggressive case of postmenopausal endometriosis
with an aromatase inhibitor has been strikingly successful, large clinical trials are required to …

Emerging molecular approaches to pain therapy

M Williams, EA Kowaluk, SP Arneric - Journal of medicinal …, 1999 - ACS Publications
… Patients who expect pain relief and know how to request it....are more likely to have … relief.
With the time taken to evaluate NSAIDs and opioids, patients who finally achieve pain relief

[PDF][PDF] Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute‐on‐chronic liver failure: the RELIEF trial

…, R Williams, V Arroyo, RELIEF Study Group - …, 2013 - Wiley Online Library
Acute‐on‐chronic liver failure (ACLF) is a frequent cause of death in cirrhosis. Albumin
dialysis with the molecular adsorbent recirculating system (MARS) decreases retained …

The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism

SA Lipton - Current Alzheimer Research, 2005 - ingentaconnect.com
… Previous cholinergic drugs only offered symptomatic relief from Alzheimer’s disease, while
memantine is believed to be the first neuroprotective drug to achieve clinical approval. The …

Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches

WJ Huang, WW Chen, X Zhang - Experimental and …, 2016 - spandidos-publications.com
… Although the molecular basis of HD is known, there is no known cure for this disease other
than symptomatic relief treatment approaches. The toxicity of mutHTT appears to be more …

Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic …

SA Lipton - NeuroRx, 2004 - Springer
Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res 37:3483–3493, …
Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nature …

Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer

G Wang, E Reed, QQ Li - Oncology reports, 2004 - spandidos-publications.com
… , many clinical trials have demonstrated that cisplatin-based chemotherapy not only improves
survival rates significantly in patients with NSCLC, but also provides symptom relief (5,19). …