Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

NP van Erp, K Eechoute, AA van der Veldt… - Journal of Clinical …, 2009 - ascopubs.org
… risk for sunitinib-induced toxicity. The aim of this study is to identify genetic markers in sunitinib
… that predispose for development of common sunitinib related toxicities: thrombocytopenia, …

Sunitinib in the treatment of thyroid cancer

SM Ferrari, M Centanni, C Virili… - Current medicinal …, 2019 - ingentaconnect.com
… This study suggested that sunitinib could be effective in DTC. In a further study, the
efficacy of sunitinib on cell growth, signal transduction pathways, and thyroid-specific gene …

Study on the mechanism and intervention strategy of sunitinib induced nephrotoxicity

J Xiao, J Wang, L Yuan, L Hao, D Wang - European Journal of …, 2019 - Elsevier
… and experimental study of sunitinib, we found that sunitinib can cause extensive renal …
sunitinib. Thus, our research will provide a theoretical basis for the future rational use of sunitinib

New strategies in kidney cancer: therapeutic advances through understanding the molecular basis of response and resistance

BI Rini - Clinical Cancer Research, 2010 - AACR
… outcome in RCC with sunitinib and axitinib, small molecule VEGF receptor inhibitors, and …
the expected duration of sequential single agent efficacy is not achievable with current agents. …

Molecular and functional analysis of sunitinib-resistance induction in human renal cell carcinoma cells

M Rausch, A Rutz, PM Allard… - … Journal of Molecular …, 2021 - mdpi.com
… anti-cancer efficacy, as well as the pharmacokinetics of sunitinib and its active … sunitinib in
human ccRCC cell lines can be established in the laboratory environment to induce molecular

… proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal …

RJ Motzer, TE Hutson, GR Hudes, RA Figlin… - Cancer chemotherapy …, 2014 - Springer
… the VEGF-A gene have also been associated with efficacy for mRCC patients receiving
axitinib [7], whereas SNPs in the VEGFR3 gene have been associated with sunitinib efficacy [10]. …

From resistance to sensitivity: insights and implications of biphasic modulation of autophagy by sunitinib

AK Abdel-Aziz, AB Abdel-Naim, S Shouman… - Frontiers in …, 2017 - frontiersin.org
… We primarily screened the anticancer efficacy of a broad range of sunitinib concentrations
against a panel of human cancer cell lines representative of diverse types; renal cell …

Comparing the efficacy of sunitinib with sorafenib in xenograft models of human hepatocellular carcinoma: mechanistic explanation

H Huynh, SP Choo, HC Toh, WM Tai… - Current Cancer Drug …, 2011 - ingentaconnect.com
… In this study, we aimed to compare the efficacy of sunitinib … We reported that sorafenib
and sunitinib suppressed tumor … than that of 40 mg/kg sunitinib. Sorafenib inhibited p-eIF4E …

[PDF][PDF] Efficacy and safety of sunitinib on metastatic renal cell carcinoma: a single-institution experience

E Hwang, HJ Lee, CK Sul… - Korean Journal of …, 2010 - synapse.koreamed.org
… the efficacy and safety of the tyrosine kinase inhibitor sunitinibSunitinib was administered
orally at a dose of 50 mg daily until … Conclusions: Sunitinib was efficacious in the treatment of …

Role of IL13RA2 in sunitinib resistance in clear cell renal cell carcinoma

N Shibasaki, T Yamasaki, T Kanno, R Arakaki… - PloS one, 2015 - journals.plos.org
sunitinib, we identified interleukin 13 receptor alpha 2 (IL13RA2) as a candidate molecule
associated with the acquired sunitinib-… However, despite the efficacy of sunitinib, ccRCC often …