… To our knowledge, this is the first study to clearly show that the clinical efficacy of sunitinib
on ccRCC is mediated primarily through an antiangiogenic effect and also not through direct …

… with the tyrosine kinase inhibitor sunitinib. We discuss the molecular basis for such a response
… VEGF and platelet-derived growth factor (PDGF) against which sunitinib has efficacy (17). …

… These findings formed the basis for sunitinib’s labeling … The efficacy of sunitinib continues
to be examined in Phase II … drug for a sufficient duration to assess efficacy. Of these 32, only 4 …

… Definitive efficacy of sunitinib from clinical trials has been shown in advanced renal …
approval of sunitinib for the treatment of these two diseases (9, 10). Clinically, sunitinib antitumor …

… molecular targets for therapeutic inhibition by the small-molecule kinase inhibitor sunitinib
… Three patients could not be evaluated for efficacy by MRI according to the protocol because …

… Taken together, the clinical observations, laboratory analyses, and previous molecular
knowledge on sunitinib are consistent in supporting the view that sunitinib's effectiveness in these …

… assess efficacy and safety of regorafenib in patients with metastatic or unresectable GIST,
progressing after failure of at least previous imatinib and sunitinib. We report the efficacy and …

… to overcome resistance to sunitinib. Importantly, a … sunitinib. Pharmacologic inhibition of
autophagy with the lysosomotropic analog Lys05 inhibited autophagy and enhanced sunitinib-…

… Therefore, if induction of hypothyroidism is part of the mode of action of sunitinib and sorafenib
and a surrogate of efficacy, then levothyroxine replacement therapy could undermine the …

… In this review an extensive summary of the molecular basis of action, pharmacodynamic and
pharmacokinetic properties, safety profile, efficacy, and biomarkers of sunitinib activity in first…