… At the same time, sunitinib (SU) has become the second-line recommended drug for GISTs
because of its efficacy. We initiated a systematic review to compare the efficacy of SU after …

… molecular target, member molecules of this validated drug class exhibit distinct clinical efficacy
… The plus-JM complexes with inhibitors axitinib and sunitinib show the JM to fold into the …

… In this review we focus on a typical TKI sunitinib and summarize the up-to-date knowledge
of sunitinib-induced cardiac abnormalities reported in clinical studies, weighing their …

… a better understanding of mutation analysis related to efficacy. A study in paediatric patients
is … , sunitinib belongs to a new class of multitargeted compounds that shows efficacy and was …

… In the second phase II study, in which 106 patients were treated with sunitinib (1 patient
was excluded from the efficacy analysis), the overall investigator-assessed objective response …

… , placebo-controlled trial definitively demonstrated the efficacy of sunitinib in the treatment
of imatinib-resistant patients with GIST [46, 47]. Sunitinib was administered at 50 mg per day in …

… of sunitinib efficacy in routine practice, because imatinib-resistant GISTs are genetically
very heterogeneous. Several teams have shown that, in most cases, the evolution of imatinib …

… in sunitinib-treated patients with metastatic renal cell carcinoma was associated with its
antitumor efficacy and … whether sunitinib-associated HTN could be a biomarker of efficacy without …

… impact of sunitinib on both chemotherapeutic efficacy and nephrotoxicity of cisplatin. … if
sunitinib could alter the antitumor effect of cisplatin in vivo and thus, modify its therapeutic efficacy. …

… sunitinib therapy. Second, using an in vitro model, we tested the efficacy of novel TKI on the
sunitinib-… Furthermore, to predict patterns of mutations arising during sunitinib therapy, we …