[HTML][HTML] New molecularly targeted drugs for gist after imatinib, sunitinib and regorafenib: A narrative review

A Mazzocca, A Minelli, F Paternostro… - Gastrointestinal …, 2022 - gist.amegroups.org
… is enrolling patients to investigate the efficacy of ripretinib compared to sunitinib as second-line
… driver has resulted from breakthroughs in understanding the molecular basis of GIST. …

Sunitinib, a clinically used anticancer drug, is a potent AChE inhibitor and attenuates cognitive impairments in mice

L Huang, J Lin, S Xiang, K Zhao, J Yu… - ACS Chemical …, 2016 - ACS Publications
… the molecular basis of the interaction between sunitinib and AChE by using molecular … ,
thus far AChE inhibitors have not been particularly efficacious for the treatment of AD. (27) On the …

Sunitinib for advanced renal cell cancer

C Coppin - Biologics: targets and therapy, 2008 - Taylor & Francis
Efficacy is well established for sunitinib as initial therapy for good-to-moderate prognosis
patients with metastatic renal cell cancers and a majority clear cell component. Benefits in …

Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor …

Y Kodera, Y Katanasaka, Y Kitamura, H Tsuda… - Breast Cancer …, 2011 - Springer
Sunitinib is a multi-kinase inhibitor that blocks receptor tyrosine kinase activity, including that
of vascular endothelial growth factor receptors (VEGFRs). Although sunitinib … of sunitinib on …

Predicting efficacy of sunitinib in metastatic renal cell carcinoma

C Ganini, C Porta - Current Biomarker Findings, 2014 - Taylor & Francis
… metastatic RCC treated with sunitinib; even if NT-pro-BNP is not a molecule that interacts
directly … that we are talking about drugs, such as sunitinib, which have been shown to have toxic …

Clinical efficacy and safety of sunitinib after imatinib failure in Japanese patients with gastrointestinal stromal tumor

K Matsumoto, A Sawaki, N Mizuno… - Japanese journal of …, 2011 - academic.oup.com
… most important purpose of sunitinib treatment is to maintain previous activities of daily living.
Maximum efficacy of antitumor therapy relates to sufficient dose and time. Sunitinib is a well-…

Sunitinib in refractory adrenocortical carcinoma: a phase II, single-arm, open-label trial

M Kroiss, M Quinkler, S Johanssen… - The Journal of …, 2012 - academic.oup.com
… Importantly, the clinical efficacy of sunitinib in ACC might be underestimated in our trial for
… of mitotane with sunitinib may have greatly reduced the exposure to sunitinib, as will be …

Efficacy and safety of sunitinib in Chinese patients with imatinib-resistant or-intolerant gastrointestinal stromal tumors

J Li, J Gao, J Hong, L Shen - Future Oncology, 2012 - Taylor & Francis
… its superior efficacy as measured … efficacy and safety of sunitinib in Chinese patients. In
this retrospective study, we report findings from an analysis of the efficacy and safety of sunitinib

Circulating proteins as potential biomarkers of sunitinib and interferon-α efficacy in treatment-naïve patients with metastatic renal cell carcinoma

CS Harmon, SE DePrimo, RA Figlin, GR Hudes… - Cancer chemotherapy …, 2014 - Springer
… significantly higher in the sunitinib arm (ORR 47 … sunitinib and IFN-α arms, respectively (P
= 0.051) [4, 13]. Here, we have investigated potential biomarkers of sunitinib and IFN-α efficacy

Pharmacological interaction with sunitinib is abolished by a germ‐line mutation (1291T>C) of BCRP/ABCG2 gene

H Kawahara, K Noguchi, K Katayama… - Cancer …, 2010 - Wiley Online Library
… To our surprise, sunitinib showed only marginal ability to … variants were all sensitive to sunitinib
with comparable efficacy. … of the molecular basis of the pharmacokinetics of sunitinib and …